Abstract

Provided are methods of treating infectious diseases by administering a BCL-2 inhibitor and a MCL-1 inhibitor to a subject in need thereof. One such infectious disease is an infection of Mycobacterium tuberculosis. Also provided are methods of inhibiting the growth of Mycobacterium tuberculosis in a granuloma by contacting the granuloma with a BCL-2 inhibitor and a MCL-1 inhibitor.

Application Number

PCT/US2021/047074

Date of Application

March 3, 2022

Inventors

Larry S. Schlesinger and Eusondia Arnett