A full-time Research Assistant position in Molecular Biology/Genetics is available in a multidisciplinary team led by Dr. Diako Ebrahimi and Dr. Smita Kulkarni. The qualified candidate will be working on projects related to virology and cancer. The Research Assistant will be applying molecular and cellular biology/virology techniques such as DNA/RNA extraction, infectivity assays, CRISPR, Western Blots, and sequencing to understand the molecular determinants of viral and cancer mutagenesis.
Texas Biomed provides unique research and training opportunities for its employees, including access to exceptional resources such as BSL4, SNPRC (Southwest National Primate Research Center), a vigorous infectious disease program on HIV, malaria, schistosomiasis, Ebola, Zika, hepatitis C and TB, and outstanding imaging, computational, and sequencing facilities. Texas Biomed faculty have adjunct appointments at two universities in San Antonio (UTSA and UTHSCSA), which provide a wide range of additional training and career development opportunities for employees at Texas Biomed.
- D. Ebrahimi et al., Genetic and Mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease. Nature Communications 2018, 9(1), 4137. PMCID: PMC6175962.
- H. Alinejad-Rokny et al. Source of CpG depletion in the HIV-1 genome. Molecular biology and Evolution 2016, 33(12), 3205. PMID: 27682824
- V. Ramsuran et al., Variation in the untranslated genome and susceptibility to infections. Frontiers in Immunology 2019, 20(7), 824. PMCID: PMC6584055
Under the direction of the PIs and research staff, the successful candidate will perform daily activities in the lab, including:
- Independently perform routine and non-routine experiments involving techniques such as cloning, cell transfection, DNA/RNA extraction & analysis, flow cytometry, PCR, agarose gel electrophoresis, SDS-PAGE, quantitative PCR; Western blot, cell culture, luciferase assays, ELISA, RNA immunoprecipitation and sequencing
- Ensure quality control of equipment, reagents, and cellular components
- Ordering and inventory of laboratory supplies and reagent/sample logs
- Other duties as assigned.
EDUCATION/EXPERIENCE/SKILLS: Required: BS in a virology, biochemistry, genetics, or a related discipline. Experience in standard lab techniques such as RNA/DNA extraction, PCR, sequencing, flow cytometry, immunoassays, Knocking down/out genes, etc. Willing to learn new techniques required for the projects. Preferred: Experience in BSL2+; experience in working with HIV-1; knowledge of data analysis, standard statistical tests, bioinformatics; familiarity with databases such as Los Alamos, UCSC Genome Browser, 1000Genomes, TCGA, and ICGC.
POTENTIAL HAZARDS: Employee will work with tissue, blood, cultures or animals containing, or potentially containing, human immunodeficiency virus (HIV) and cell culture lines infected with human or animal pathogens (other than HIV or Herpes B virus). Will work with the following biological agents (recombinant DNA/RNA) and infectious agents. Will work in a BSL2 laboratory. Participation in a medical monitoring and surveillance program is required. Must be able to wear an air-purifying respirator in a proper manner and, if necessary, pass a respirator fitness test. Safety training, equipment, clothing and supplies will be provided.
OTHER: This is a full-time salaried (exempt) position. Texas Biomedical Research Institute business hours are Monday through Friday – 8:00 a.m. to 5:00 p.m. Occasional after hours or weekend cell culture maintenance will be necessary. Texas Biomed is committed to a drug-free workplace. Pre-employment drug screen is required.
Apply online at http://www.txbiomed.org/about/employment. Application packets are accepted electronically or in hard copy. A completed application packet is a requirement for all positions. Incomplete applications will not be accepted. Equal Employment Opportunity/M/F/Disability/Protected Veteran Status
Your resume and application must be provided electronically. Please follow the steps below.
- Please read instructions before submitting your application.
- PDF forms will need to be completed, saved to your computer and uploaded. Please refer to Step 2 for additional information.
- Fill out the online form.
- At the conclusion of the application process, you will be asked to attach your PDF files.