Dr. Fish is the lab manager for Deepak Kaushal, Ph.D., the director of the Southwest National Primate Research Center at Texas Biomedical Research Institute. She moved from Louisiana with Dr. Kaushal in January of 2019 and was promoted from postdoctoral research to lab manager. As the lab manager, Dr. Fish is directly involved in all research projects with the Kaushal Lab, which utilizes the macaque as a model of TB and TB/AIDS co-infection using the natural route of infection.
Prior to her work with Tuberculosis, Dr. Fish worked with Spotted fever group rickettsial species including Rickettsia rickettsii and R. conorii, at the Louisiana State University School of Veterinary Medicine. Her research was dedicated to understanding and characterizing how rickettsia evade the hosts innate immune system upon inoculation into the mammalian host’s blood stream prior to establishing an infection.
Inside the Lab
In the lab, Dr. Fish works with all the members of the Kaushal lab to facilitate the overall research interests of Dr. Kaushal as well as each individual’s research projects. She plays an integral part of the lab as she is responsible for creation and execution of all administrative documents including biosafety and animal use documents. Dr. Fish also manages all animal studies and coordinates with the onsite veterinarians for all nonhuman primate work. She is also actively involved in several committees across Texas Biomed involved in environmental, community and campus safety.
In addition to her administrative responsibilities, Dr. Fish is actively involved in all ongoing studies in the Kaushal lab. The areas of research in the lab cover several important aspects of TB infection such as understanding the response of Mtb to in vivo stressors; elucidating the role of inducible bronchus associated lymphoid tissue (iBALT) in granuloma formation and protection from active disease; identifying T-cell based antigen specific responses associated with latent versus active disease in TB and TB/HIV coinfection.
Main Technologies and Methods Used
- Gene Cloning and Protein Expression
- Protein Purification
- Biochemical and Functional Analysis of Proteins
- Western Immunoblotting
- Immunofluorescence microscopy
- Bacterial and Mammalian Cell Culture Techniques
- Bacterial Culture and Growth Assays
- Flow Cytometry