Dr. Worwa received her veterinary doctoral training at the Institute of Virology and Immunology (IVI), Switzerland’s National Reference Laboratory for Highly Contagious Animal Diseases and the School of Veterinary Medicine, University of Bern, Switzerland. Prior to joining Texas Biomed in 2013, Dr. Worwa conducted postdoctoral studies at the School of Veterinary Medicine, University of California at Davis.
A classically trained virologist and veterinarian, Dr. Worwa is highly skilled and certified for work within high containment animal biosafety laboratories at the ABSL-3 and ABSL-4 levels. She currently works with Ebola virus, Sudan virus, Marburg virus and Western Equine Encephalitis virus with a focus on disease models. Dr. Worwa has more than 10 years of expertise studying veterinary and human viruses.
Inside the Lab
As part of Dr. Anthony Griffith’s research team, Dr. Worwa is working on droplet transmission of filoviruses and alphaviruses. In an effort to model disease in vivo, Dr. Worwa utilizes the Biaera Aerosol Exposure System to characterize the infectivity of different virus stocks and generate aerosols of varying sizes required for respiratory airway deposition. Dr. Worwa’s in vitro research focuses on the gene and protein expression following infection with these viruses to gain insight into viral biology.
As the responsible veterinarian for multiple grants received by Texas Biomed scientists, Dr. Worwa is also involved in a variety of projects that evaluate medical countermeasures against filoviruses. This includes animal studies in biocontainment, whereby she oversees the health and well-being of animals in compliance with Good Laboratory Practice (GLP) and Animal Rule regulations of the Food and Drug Administration (FDA).
Main Technologies and Methods Used
- Biaera Aerosol Exposure Platform
- Jet RIP plethysmography system
- Aerosol particle characterization
- Spray factor determinations
- Animal models
- PCR, qRT-PCR
- Viral infectivity and propagation
- Plaque assay titrations, plaque reduction neutralization assays
- SDS-PAGE, Western blot
- Primary and secondary cell culture techniques