Dr. Dwivedi’s research focuses on understanding the host immune responses and developing novel vaccines against infectious pathogens of animals and humans. Currently, his research goal to develop an effective vaccine against Tuberculosis. Tuberculosis is leading cause of mortality, associated with more than 1.3 million deaths each year. Currently, Due to the failure of the only available vaccine (BCG) and emergence of multidrug resistant strain and long treatment regimen warrant an effective vaccine for disease control.
Inside the Lab
Working as a staff scientist in Dr. Joanne Turner’s lab, Dr. Dwivedi’s research is focused on the pathogenesis of M. tuberculosis and vaccine development. He is primarily studying a chemokine Interleukin-10 (IL-10), which plays a critical role in TB disease progression and known as a correlate of susceptibility to develop tuberculosis, however its mechanism is not fully understood. His main research focus is to study that how IL-10 influences the host immune response during the course of M. tuberculosis infection. He is also studying how IL-10 modulation impacts the vaccine and drug efficacy in murine tuberculosis.
Main Technologies and Methods Used
- Isolation and characterization of murine mononuclear cells
- Flow Cytometry