TPLH has assembled a colony of baboons between 0 and 25 years of age (0 to 100 human equivalent). In addition to studies on postnatal animals across the life-course, the TPLH NICHD Program Project Grant, in year 22, supports studies on mothers and their fetuses throughout pregnancy. Several well-established, funded investigator groups are collaborating in either individual projects or multidisciplinary, multi-institution projects studying these animals.
We have considerable experience in conducting long-term in vivo physiological studies using free moving animals on a tether system to study endocrine, cardiovascular, and metabolic endpoints. We have an extensive archive of frozen and fixed brain tissues from fetuses and pregnant baboons from 0.5 gestation to term and across the life-course.
We are developing a multi-institution, multidisciplinary project to develop the power of this unique nonhuman primate colony to evaluate effects of the following on brain development and function:
- health of mothers and sires before pregnancy;
- outcomes of developmental programming challenges, such as sub-optimal maternal nutrition (under- and over-nutrition), maternal stress, and exposure to environmental pollutants and obstetric pharmacological agents administered to mothers in pregnancy and lactation;
- normal life course aging.