Texas Pregnancy & Life-course Health Research Center

Books

Life in the WombNathanielsz, P. W. (2001) The Prenatal Prescription. Harper Collins. This book is already in translation into French, German, Portuguese, Korean, Spanish and Polish. This book is a slimmed down version of Life in the Womb.

Nathanielsz, P. W. (1999) Life in the Womb: The Origin of Health and Disease. Promethean Press, Ithaca, NY. A book on the programming of life-time health for the lay public.

Nathanielsz, P. W. (1992) Life Before Birth and A Time to Be Born. Promethean Press. Ithaca, New York. A book on fetal development and the birth process for the lay public, repeatedly reprinted and translated into many languages.

Primary Papers, Reviews, & Book Chapters
(organized by species)

rat_silhouette

Rodent Investigations

2017

Zou, T., Chen, D., Yang, Q., Wang, B., Zhu, M.-J., Nathanielsz, P.W., Du, M. (2017) Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. J Physiol (Lond). PMID 27891610.

2016

Bautista, C.J., Montaño, S., Ramirez, V., Morales, A., Nathanielsz, P.W., Bobadilla, N.A., Zambrano, E. (2016) Changes in milk composition in obese rats consuming a high-fat diet. Br J Nutr 115:538–546. PMID 26608475.

Liang, X., Yang, Q., Fu, X., Rogers, C.J., Wang, B., Pan, H., Zhu, M.-J., Nathanielsz, P.W., Du, M. (2016) Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. J Physiol (Lond) 594:4453–4466. PMID 27060371.

Vega CC, Reyes-Castro LA, Rodríguez-González GL, Bautista CJ, Vázquez-Martínez M, Larrea F, Chamorro-Cevallos GA, Nathanielsz PW, Zambrano E. (2016) Resveratrol partially prevents oxidative stress and metabolic dysfunction in pregnant rats fed a low protein diet and their offspring. J Physiol (Lond) 594:1483–1499. PMID 26662841.

2015

Reyes-Castro, L. A., Rodríguez-González, G. L., Chavira, R., Ibáñez, C., Lomas-Soria, C., Rodriguez, J. S., Nathanielsz, P. W., Zambrano, E. (2015) Paternal line multigenerational passage of altered risk assessment behavior in female but not male rat offspring of mothers fed a low protein diet. Physiol Behav 140: 89–95. PMID 25496979.

Rodríguez-González, G. L., Vega, C. C., Boeck, L., Vázquez, M., Bautista, C. J., Reyes-Castro, L. A., Saldaña O., Lovera, D., Nathanielsz, P. W., Zambrano, E. (2015) Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility. Int J Obes (Lond) 39(4): 549–556. PMID 25504042.

Santos, M., Rodríguez-González, G. L., Ibáñez, C., Vega, C. C., Nathanielsz, P. W., & Zambrano, E. (2015) Adult exercise effects on oxidative stress and reproductive programming in male offspring of obese rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(3): R219–225. PMID 25502750.

Vega, C. C., Reyes-Castro, L. A., Bautista, C. J., Larrea, F., Nathanielsz, P. W., & Zambrano, E. (2015) Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism. Int J Obes (Lond) 39(4): 712–719. PMID 23949616.

Zambrano, E., Reyes-Castro, L. A., & Nathanielsz, P. W. (2015) Aging, glucocorticoids and developmental programming. Age (Dordrecht, Netherlands), 37(3): 9774. PMID 25953670.

2014

Cervantes-Rodríguez, M., Martínez-Gómez, M., Cuevas, E., Nicolás, L., Castelán, F., Nathanielsz, P. W., Zambrano, E., Rodríguez-Antolín, J. (2014) Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect. Br J Nutr 111: 616-624. PMID 24124655.

Rodríguez-González, G. L., Reyes-Castro, L. A., Vega, C. C., Boeck, L., Ibáñez, C., Nathanielsz, P. W., Larrea, F., Zambrano, E. (2014) Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress. Age (Dordr) 36(6): 9721. PMID 25354645.

2013

Bautista, C. J., Rodríguez-González, G. L., Torres, N., Hernández-Pando, R., Ramírez, V., Rodríguez-Cruz, M., Nathanielsz, P. W., Zambrano, E. (2013) Protein Restriction in the Rat Negatively Impacts Long-chain Polyunsaturated Fatty Acid Composition and Mammary Gland Development at the End of Gestation. Arch Med Res. 44(6): 429–436. PMID 24051037.

Vega, C. C., Reyes-Castro, L. A., Bautista, C. J., Larrea, F., Nathanielsz, P. W., Zambrano, E. (2013) Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism. Int J Obes (Lond). PMID 23949616.

2012

Morimoto S, Sosa TC, Calzada L, Reyes-Castro LA, Díaz-Díaz E, Nathanielsz PW and Zambrano E. (2012) Developmental programming of aging of isolated pancreatic islet glucose stimulated insulin secretion in female offspring of mothers fed low protein diets in pregnancy and/or lactation. Journal of DOHaD 3(6): 483-488.

Reyes-Castro, L. A., Rodriguez, J. S., Charco, R., Bautista, C. J., Larrea, F., Nathanielsz, P. W. and Zambrano, E. (2012) Maternal protein restriction in the rat during pregnancy and/or lactation alters cognitive and anxiety behaviors of female offspring. Int J Dev Neurosci 30: 39-45

Rodriguez, J.S., Rodríguez-González, G.L., Reyes-Castro, L.A., Ibáñez, C., Ramírez, A., Chavira, R., Larrea, F., Nathanielsz, P.W. and Zambrano, E. (2012) Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation. Int J Dev Neurosci 30: 75-81.

Rodríguez-González GL, Vigueras-Villaseñor RM, Trejo R, Nathanielsz PW, Larrea F, Zambrano E. (2012) Maternal protein restriction in pregnancy and/or lactation affects seminiferous tubule organization in male rat offspring. Journal of DOHaD 3(5): 321-326.

Rodríguez-Trejo, A., Ortiz-López, M.G., Zambrano, E., Granados-Silvestre, M.D., Méndez-Herrera, C., Blondeau, B., Bréant, B., Nathanielsz, P.W. and Menjivar, M. (2012) Developmental programming of neonatal pancreatic β-cells by a maternal low protein diet in rats involves a switch from proliferation to differentiation. Am J Physiol Endocrinol Metab 302(11): E1431-E1439.

2011

Morimoto S, Calzada L, Sosa TC, Reyes-Castro LA, Rodriguez-González GL, Morales A, Nathanielsz PW, Zambrano E. (2011) Emergence of ageing-related changes in insulin secretion by pancreatic islets of male rat offspring of mothers fed a low-protein diet. Br J Nutr 107(11): 1562-1565. PMID 21902873.

2010

Reyes-Castro LA, Rodriguez JS, Rodríguez-González GL, Wimmer RD, McDonald TJ, Larrea F, Nathanielsz PW, Zambrano E. (2010) Pre- and/or postnatal protein restriction in rats impairs learning and motivation in male offspring. Int J Dev Neurosci 29(2): 177–182. PMID 21078378.

Zambrano E, Martínez-Samayoa PM, Rodríguez-González GL, Nathanielsz PW. (2010) Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats. J Physiol 15;588(Pt 10): 1791-9. PMID 20351043.

2009

Cox LA, Nathanielsz PW (2009) The importance of altered gene promoter methylation and transcription factor binding in developmental programming of central appetitive drive. J Physiol 587(20): 4763-4764.

Torres N, Bautista CJ, Tovar AR, Ordaz G, Rodriguez-Cruz, M, Ortiz V, Granados O, Nathanielsz PW, Larrea F, Zambrano E. (2009) Protein restriction during pregnancy affects maternal iver lipid metabolism and fetal brain lipid composition in the rat. Am J Physiol Endocrinol Metab 298(2): E270-E277.

2008

Bautista, C.J., Boeck, L., Larrea, F., Nathanielsz, P.W., Zambrano, E. (2008) Effects of a maternal low protein isocaloric diet on milk leptin and progeny serum leptin concentration and appetitive behavior in the first 21 days of neonatal life in the rat. Pediatr Res 63(4):358-63.

2007

McDonald, T.J., Nijland, M.J., Nathanielsz, P.W. (2007) The insulin-like growth factor system and the fetal brain: effects of poor maternal nutrition. Rev Endocr Metab Disorder 8(2):71-84.

2006

Guzman, C., Cabrera, R., Cardenas, M., Larrea, F., Nathanielsz, P.W., Zambrano, E. (2006) Protein restriction during fetal and neonatal development in the rat alters reproductive function and accelerates reproductive aging in female progeny. J Physiol 572:97-108

Nathanielsz, P.W. (2006) Decreased placental amino acid transport and intrauterine growth restriction, which is chicken and which the egg? J Physiol 576(Pt.3): 649.

Zambrano, E., Bautista, C.J., Deas, M., Martinez-Samayoa, P.M., Gonzalez-Zamorano, M., Ledesma, H. Morales, J., Larrea, F., Nathanielsz, P.W. (2006) A low maternal protein diet during pregnancy and lactation has sx and window of exposure specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol 571: 221-230.

2005

Zambrano E, Martinez-Samayoa PM, Bautista CJ, Deas M, Guillen L, Rodriguez-Gonzalez GL, Guzman C, Larrea F, Nathanielsz PW. (2005) Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation. J Physiol 566: 225-236.

2003

McDonald, T.J., Franko, K.I., Brown, J.M., Jenkins, S.L., Nathanielsz, P.W. (2003) Betamethasone in the last week of pregnancy causes fetal growth retardation but not adult hypertension in rats. J Soc Gynecol Invest 10(8): 469-473.

Zambrano E, Rodriguez-Gonzalez GL, Guzman C, Garcia-Becerra R, Boeck L, Diaz L, Menjivar M, Larrea F, Nathanielsz PW (2005) A maternal low protein diet during pregnancy and lactation in the rat impairs male reproductive development. J Physiol 563: 275-284.

1998

Umsheid, C.A., Wu, W.X., Gordan, P., Nathanielsz, P.W. (1998) Up-regulation of oxytocin receptor messenger ribonucleic acid and protein by estradiol in the cervix of ovariectomized rat. Biol Reprod 59: 1131-1138.

1997

Gordon, P., Jenkins, S.L., Wentworth, R.A., Nathanielsz, P.W. (1997) Effect of in vivo estradiol administration to bilaterally ovariectomized rats on in vitro myometrial responsiveness to prostaglandin F2α and oxytocin. Biol Reprod 57: 597-601.

 

monkey_silhouette

Nonhuman Primate Investigations

2017

Kuo, A.H., Li, J., Li, C., Huber, H.F., Schwab, M., Nathanielsz, P.W., Clarke, G.D. (2017) Prenatal steroid administration leads to adult pericardial and hepatic steatosis in male baboons. Int J Obes (Epub ahead of print). PMID 28337030.

Kuo, A.H., Li, C., Li, J., Huber, H.F., Nathanielsz, P.W., Clarke, G.D. (2017) Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing. J Physiol (Lond) 595:1093–1110. PMID 27988927.

2016

Hellmuth, C., Uhl, O., Kirchberg, F.F., Harder, U., Peissner, W., Koletzko, B., Nathanielsz, P.W. (2016) Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation. Nutr Metab Cardiovasc Dis 26:786–796. PMID 27146364.

Pantham, P., Rosario, F.J., Weintraub, S.T., Nathanielsz, P.W., Powell, T.L., Li, C., Jansson, T. (2016) Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in maternal nutrient restricted baboons. Biol Reprod 95:98. PMID 27605346.

Wu, A., Dong, Q., Gao, H., Shi, Y., Chen, Y., Zhang, F., Bandyopadhyay, A., Wang, D., Gorena, K.M., Huang, C., Tardif, S., Nathanielsz, P.W., Sun, L.-Z. (2016) Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosets. Sci Rep 6:32190. PMID 27558284.

2015

Ek, C. J., Nathanielsz, P., Li, C., & Mallard, C. (2015) Transcriptomal changes and functional annotation of the developing non-human primate choroid plexus. Front Neurosci 9: 82. PMID 25814924

Huber, H. F., Ford, S. M., Bartlett, T. Q., & Nathanielsz, P. W. (2015) Increased aggressive and affiliative display behavior in intrauterine growth restricted baboons. J Med Primatol 44(3): 143–157. PMID 25891005.

Huber HF, Gerow KG, Nathanielsz PW. (2015) Walking speed as an aging biomarker in baboons (Papio hamadryas). J Med Primatol 44(6):373-380. PMID 26411922.

Nathanielsz PW, Yan J, Green R, Nijland M, Miller JW, Wu G, McDonald TJ, Caudill MA. (2015) Maternal obesity disrupts the methionine cycle in baboon pregnancy. Physiol Rep 3(11). PMID 26537341.

Pantham P, Rosario FJ, Nijland M, Cheung A, Nathanielsz PW, Powell TL, Galan HL, Li C, Jansson T. (2015) Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon. Am J Physiol Regul Integr Comp Physiol 309(7):R740-R746. PMID 26246504.

Pereira, S. P., Oliveira, P. J., Tavares, L. C., Moreno, A. J., Cox, L. A., Nathanielsz, P. W., & Nijland, M. J. (2015) Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation. Am J Physiol Renal Physiol 308(11): F1217–1228. PMID 25761880.

2014

Blanco CL, Moreira AG, McGill-Vargas LL, Anzueto DG, Nathanielsz PW, Musi N (2014) Antental corticosteroids alter insulin signaling pathways in fetal baboon skeletal muscle. J Endocrinol 221(2): 253-260. PMID 24756099.

Kavitha JV, Rosario FJ, Nijland MJ, McDonald TJ, Wu G, Kanai Y, Powell TL, Nathanielsz PW, Jansson T. (2014) Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J 28(3): 1294-305. PMID 24334703.

Keenan K, Bartlett TQ, Nijland M, Zürcher NR, Nathanielsz PW. (2014) Reply to KN Litwak and S Levin. Am J Clin Nutr 99(1): 211-2. PMID 24363259.

Phillips KA, Bales KL, Capitanio JP, Conley A, Czoty PW, Hart BA, Hopkins WD, Hu SL, Miller LA, Nader MA, Nathanielsz PW, Rogers J, Shively CA, Voytko ML. (2014) Why primate models matter. Am J Primatol 76(9): 801-27. PMID 24723482.

Tchoukalova, Y.D., Krishnapuram, R., White, U. A., Burk, D., Fang, X., Nijland, M. J., Nathanielsz, P.W. (2014) Fetal baboon sex-specific outcomes in adipocyte differentiation at 0.9 gestation in response to moderate maternal nutrient reduction. Int J Obes (Lond) 38: 224-230.

Ye, W., Xie, L., Li, C., Nathanielsz, P. W., & Thompson, B. J. (2014) Impaired development of fetal serotonergic neurons in intrauterine growth restricted baboons. J Med Primatol 43(4): 284–287. PMID 25431504

2013

Cox, L.A., Comuzzie, A. G., Havill, L. M., Karere, G. M., Spradling, K.D., Mahaney, M.C., Nathanielsz, P.W., Nicolella, D.P., Shade, R.E., Voruganti, S., VandeBerg, J.L. (2013) Baboons as a model to study genetics and epigenetics of human disease. ILAR J 54: 106-121. PMID 24174436.

Cox, L.A., Li, C., Glenn, J.P., Lange, K., Spradling, K.D., Nathanielsz, P.W., Jansson, T. (2013) Expression of the Placental Transcriptome in Maternal Nutrient Reduction in Baboons Is Dependent on Fetal Sex. J Nutr 143(11): 1698-1708. PMID 24047701.

Guo, C., Li, C., Myatt, L., Nathanielsz, P.W., Sun, K. (2013) Sexually Dimorphic Effects of Maternal Nutrient Reduction on Expression of Genes Regulating Cortisol Metabolism in Fetal Baboon Adipose and Liver Tissues. Diabetes 62: 1175-1185. PMID 23238295.

Kavitha, J.V., Rosario, F.J., Nijland, M.J., McDonald, T.J., Wu, G., Kanai, Y., Powell, T.L., Nathanielsz, P.W., Jansson, T. (2013) Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J 28(3): 1294-1305. PMID 24334703.

Keenan, K., Bartlett, T.Q., Nijland, M., Rodriguez, J.S., Nathanielsz, P.W., Zürcher, N.R. (2013) Poor nutrition during pregnancy and lactation negatively affects neurodevelopment of the offspring: evidence from a translational primate model. Am J Clin Nutr 98(2): 396-402. PMID 23783297.

Li, C., McDonald, T., Wu, G., Nijland, M., Nathanielsz, P. (2013) Intrauterine growth restriction alters term fetal baboon hypothalamic appetitive peptide balance. J Endocrinol 217: 275-282. PMID 23482706.

Li, C., Ramahi, E., Nijland, M.J., Choi, J., Myers, D.A., Nathanielsz, P.W., McDonald, T.J. (2013) Up-regulation of the Fetal Baboon Hypothalamo-Pituitary-Adrenal Axis in Intrauterine Growth Restriction: Coincidence with Hypothalamic Glucocorticoid Receptor Insensitivity and Leptin Receptor Down-regulation. Endocrinology 154: 2365-2373. PMID 23625543.

Li, C., Shu, Z.J., Lee, S., Gupta, M.B., Jansson, T., Nathanielsz, P.W., Kamat, A. (2013) Effects of maternal nutrient restriction, intrauterine growth restriction, and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro. J Med Primatol 42(4): 211-219. PMID 23600855.

Maitra, M., Dey, M., Yuan, W.C., Nathanielsz, P.W., Garcia, C.K. (2013) Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells. J Biol Chem 288: 27159-27171.23926107.

Maloyan, A., Muralimanoharan, S., Huffman, S., Cox, L.A., Nathanielsz, P.W., Myatt, L., Nijland, M.J. (2013) Identification and Comparative Analyses of Myocardial miRNAs Involved in the Fetal Response to Maternal Obesity. Physiol Genomics 45(19): 889-900. PMID 23922128.

McDonald TJ, Wu G, Nijland MJ, Jenkins SL, Nathanielsz PW, Jansson T. (2013) Effect of 30% nutrient restriction in the first half of gestation on maternal and fetal baboon serum amino acid concentrations. Br J Nutr 109(8): 1382-88. PMID 23046718.

Xie, L., Antonow-Schlorke, I., Schwab, M., McDonald, T.J., Nathanielsz, P.W., Li, C. (2013) The frontal cortex IGF system is down regulated in the term, intrauterine growth restricted fetal baboon. Growth Horm IGF Res 23(5): 187-192.

2012

Reardon, H.T., Hsieh, A.T., Jung Park, W., Kothapalli, K.S., Anthony, J.C., Nathanielsz, P.W., Thomas Brenna, J. (2012) Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. Prostaglandins Leukot Essent Fatty Acids 88(1): 15–19.

Rodriguez, J.S., Bartlett, T.Q., Keenan, K.E., Nathanielsz, P.W., Nijland, M.J. (2012) Sex-dependent cognitive performance in baboon offspring following maternal caloric restriction in pregnancy and lactation. Reprod Sci 19: 493-504.

2011

Antonow-Schlorke I, Schwab M, Cox LA, Li C, Stuchlik K, Witte OW, Nathanielsz PW, McDonald TJ. (2011) Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. Proc Natl Acad Sci USA 108(7): 3011-3016. PMID 21252306.

Choi J, Li C, McDonald TJ, Comuzzie AG, Mattern V, Nathanielsz PW (2011) Emergencc of insulin resistance in juvenile baboon offspring of mothers exposed to moderate maternal nutrient reduction. Am J Physiol Regul Integr Comp Physiol 301(3): R757-R762. PMID 21653880.

Kamat A, Nijland MJ, McDonald TJ, Cox LA, Nathanielsz PW, Li C. (2011) Moderate global reduction in maternal nutrition has differential stage of gestation specific effects on β 1- and β 2-adrenergic receptors in the fetal baboon liver. Reprod Sci 18(4): 398-405. PMID 21079239.

Rodriguez JS, Zϋrcher NR, Bartlett TQ, Nathanielsz PW, Nijland MJ. (2011) CANTAB delayed matching to sample task performance in juvenile baboons. J Neurosci Methods 196(2): 258-263. PMID 21276821.

Rodriguez JS, Zurcher NR, Keenan KE, Bartlett TQ, Nathanielsz PW, Nijland MJ (2011) Prenatal betamethasone exposure has sex specific effects in reversal learning and attention in juvenile baboons. Am J Obstet Gynecol 204(6): 545.e1-545.e10. PMID 21411054.

2010

Cerbulo-Vazquez A, Zavala M, Perez-Palacios GA, Jenkins SL, Giavedoni LD, Hodara VL, Romero R, Wimmer RD, Irles C, Nathanielsz PW (2010) Baboon fetal arterial endothelial cells are more responsive to challenge by tumor necrosis factor alpha (TNF-alpha) than baboon fetal umbilical vein endothelial cells. Atheroslcerosis 212(2): 701-3. PMID 20638065.

Kamat A, Nijland MJ, McDonald TJ, Cox LA, Nathanielsz PW, Li C (2010) Moderate Global Reduction in Maternal Nutrition Has Differential Stage of Gestation Specific Effects on β1- and β2-Adrenergic Receptors in the Fetal Baboon Liver. Reprod Sci 18(4): 398-405. PMID 21079239.

Nijland MJ, Mitsuya K, Li, C, Ford, SP, McDonald, TJ, Nathanielsz PW, Cox LA (2010) Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability. J Physiol 588(Pt 8): 1349-59. PMID 20176628.

Rodríguez-Sánchez IP, Tejero ME, Cole SA, Comuzzie AG, Nathanielsz PW, Wallis M, Barrera-Saldaña HA. (2010) Growth hormone-related genes from baboon (Papio hamadryas): Characterization, placental expression and evolutionary aspects. Gene 450(1-2): 1-7. PMID 19651193.

Zurcher NR, Rodriguez JS, Jenkins SL, Keenan K, Bartlett TQ, McDonald TJ, Nathanielsz PW, Nijland MJ (2010) Performance of juvenile baboons on neuropsychological tests assessing associative learning, motivation and attention. J Neurosci Methods 188(2): 219-25. PMID 20170676.

2009

Farley D, Tejero ME, Comuzzie AG, Higgins PB, Cox L, Werner SL, Jenkins SL, Li C, Choi J, Dick EJ Jr, Hubbard GB, Frost P, Dudley DJ, Ballesteros B, Wu G, Nathanielsz, PW, Schlabritz-Loutsevitch NE (2009) Feto-placental Adaptations to Maternal Obesity in the Baboon. Placenta 30(9): 752-60.

Li C, Schlabritz-Loutsevitch NE, Hubbard GB, Han V, Nygard K, Cox LA, McDonald TJ, Nathanielsz PW (2009) Effects of maternal global nutrient restriction on fetal baboon hepatic IGF system genes and gene products. Endocrinology 150(10): 4634-42. PMID 19574404.

Schlabritz-Loutsevitch NE, Lopez-Alvarenga JC, Comuzzie AG, Miller MM, Ford SP, Li C, Hubbard GB, Ferry RJ, Jr., Nathanielsz PW. (2009) The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species. Reprod Sci 16(3): 308-19.

Schlabritz-Loutsevitch, N.E., Lopez-Alvarenga, J.C., Comuzzie, A.G., Miller, M., Li, C., Hubbard, G.B., Ferry, R.J., Jr., Nathanielsz, P.W. (2009) The prolonged effect of repeated maternal glucocorticoids exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species. Reprod Sci16(3): 309-19. PMID 19087979.

Schlabritz-Loutsevitch NE, Whatmore AM, Quance CR, Koylass MS, Cumins LB, Dick EJ, Jr., Snider CL, Cappelli D, Ebersole JL, Nathanielsz PW, Hubbard GB (2009) A novel Brucella isolate in association with two cases of stillbirth in non-human primates—first report. J Med Primatol 38(1): 70-3.

Tchoukalova YD, Nathanielsz PW, Conover CA, Smith SR, Ravussin E (2009) Regional variation in adipogenesis and IGF regulatory proteins in the fetal baboon. Biochem Biophys Res Commun 380(3): 679-683.

Unterberger A, Szyf M, Nathanielsz PW, Cox LA (2009) Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons. J Med Primatol 38(4): 219-227.

2008

Grieves, J.L., Dick, E.J., Jr., Schlabritz-Loutsevich, N.E., Butler, S.D., Leland, M.M., Price, S.E., Schmidt, C.R., Nathanielsz, P.W., Hubbard, G.B. (2008) Barbiturate euthanasia solution-induced tissue artifact in nonhuman primates. J Med Primatol 37(3): 154-161.

2007

Antonow-Schlorke, I., Ebert, M., Li, C., Gschanes, A., Witte, O.W., McDonald, T., Nathanielsz, P.W., Schwab, M. (2007) Lack of effect of antenatal glucocorticoid therapy in the fetal baboon on cerebral cortical glucose transporter proteins. J Med Primatol 36(1): 17-20.

Hsieh, A.T., Anthony, J.C., Diersen-Schade, D.A., Rumsey, S.C., Lawrence, P., Li, C., Nathanielsz, P.W., Brenna, J.T. (2007) The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids. Pediatr Res 61: 537–545.

Kothapalli, K.S., Anthony, J.C., Pan, B.S., Hsieh, A.T., Nathanielsz, P.W., Brenna, J.T. (2007) Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PloS One 11:2:e370.

Li, C., Levitz, M., Hubbard, GB, Jenkins, SL, Han, V, Ferry, RJ Jr, McDonald, TJ, Nathanielsz, P.W., Schlabritz-Loutsevitch NE. (2007) The IGF axis in baboon pregnancy: placental and systemic responses to feeding 70% global ad libitum diet. Placenta 28(11-12): 1200-1210.

Nijland MJ, Schlabritz-Loutsevitch N, Hubbard GB, Nathanielsz PW, Cox LA. (2007) Nonhuman Primate Fetal Kidney Transcriptome Analysis Indicates mTOR is a Central Nutrient Responsive Pathway. J Physiol 579: 643-656.

Schlabritz-Loutsevitch NE, Ballesteros B, Dudley C, Jenkins SL, Hubbard G, Burton GJ, Nathanielsz PW. (2007) Moderate maternal nutrient restriction, but not glucocorticoid administration, leads to placental morphological changes in the baboon (Papio sp.). Placenta 28(8-9): 783-793.

Schlabritz-Loutsevitch, N.E., Dudley, C.J., Gomez, J.J., Heath, N.C., Smith, B.K., Jenkins, Sl.L., McDonald, T.J., Bartlett, T.Q., Nathanielsz, P.W., Nijland, M.J. (2007) Metabolic adjustments to moderate maternal nutrient restriction. Br J Nutr 29: 1-9.

Schmitz, T., Cox, L.A., Li, C., Levine, B.A., McDonald, T.J., Nathanielsz, P.W. (2007) Prostaglanding E2 receptor expression in fetal baboon lung at 0.7 gestation following betamethasone exposure. Pediatric Research. 61(4): 421-6.

2006

Cox, L.A., Nijland, M.J., Gilbert, J.S., Schlabritz-Loutesevitch, N.E., Hubbard, G.B., McDonald, T.J., Shade, R.E., Nathanielsz, P.W. (2006) Effect of thirty percent maternal nutrient restriction from 0.16 to 0.5 gestation on fetal baboon kidney gene expression. J Physiol 572:67-85.

Cox, L.A., Schlabritz-Loutsevitch, N.E., Hubbard, G.B., Nijland, M., McDonald, T.J., Nathanielsz, P.W. (2006) Gene expression profile difference in left and right liver lobes from mid-gestation fetal baboons: A cautionary tale. J Physiol 572(1): 59-66.

Dudley, DC.J., Hubbard, G.B., Moore, C.M., Dunn, B.G., Raveendran, M., Rogers, J., Nathanielsz, P.W., McCarrey, J.R., Schlabritz-Loutsevitch, N.E. (2006) A male baboon (Papio hamadryas) with a mosaic 43,XXy/42,XY karyotype. A J Med Genet A 140A(1): 94-97.

Howell, K.H., Hubbard, G.B., Moore, C.M., Dunn, B.G., von Kap-Herr, C., Raveendran, M., Rogers, J.A., Leland, M.M., Brasky, K.M., Nathanielsz, P.W., Schlabritz-Loutsevitch, N.E. (2006) Trisomy of chromosome 18 in the baboon (Papio hamadryas anubis). Cytogenet Genome Res 112(1-2): 76-81.

Schlabritz-Loutsevitch, N.E., Hodara, V.L., Parodi, L.M., Hubbard, G.B., Jenkins, S.L., Dudley, D.J., Nathanielsz, P.W., Giavedoni, L.D. (2006) Three weekly courses of betamethasone administered to pregnant baboons at 0.6, 0.65 and 0.7 of gestation alter fetal and maternal lymphocyte populations at 0.95 of gestation. J Reprod Immunol 69(2): 149-63.

Tchirikov, M., Schlabritz-Loutsevitch, N.E., Hubbard, G.B., Tardif, S., Schroder, H.J., Nathanielsz, P.W. (2006) The ductus venosus and intrahepatic venous system in Callithrix jacchus jacchus and Macaca fascicularis fetuses. J Med Primatol 35(1): 18-24.

2005

Diau, G-Y., Hsieh, A., Sarkadi-Nagy, E., Wijendran, V., Nathanielsz, P.W., Brenna, J.T. (2005) The influence of long chain polyunsaturated supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous system. BMC 3(11): 1-12. PMID 15975147.

Schlabritz-Loutsevitch, N.E., Hubbard, G.B., Jenkins, S.L., Martin, H.C., Snider, C.S., Frost, P.A., Leland, M., Havill, L.M., McDonald, T.J., Nathanielsz, P.W. (2005) Ontogeny of hematological cell and biochemical profiles in maternal and fetal baboons (Papio species). J Med Primatol 34(4): 193-200.

Tchirikov M, Schlabritz-Loutsevitch NE, Hubbard GB, Schroder HJ, Nathanielsz PW. (2005) Structural evidence for mechanisms to redistribute hepatic and ductus venosus blood flows in nonhuman primate fetuses. Am J Obstet Gynecol 192(4): 1146-1152.

Tchirikov, M., Schlabritz-Loutsevitch, N., Nathanielsz, P.W., Beindorff, N., Schroder, H.J. (2005) Ductus venosus shunting in marmoset and baboon fetuses. Ultrasound Obstet Gynecol 26(3): 252-257.

Tchirikov, M., Schroder, H.J., Schlabritz-Loutsevitch, N., Beindorff, N., Nathanielsz, P.W., Hecher, K. (2005) The proportion of umbilical blood shunting through the ductus venosus in nonhuman primate fetuses. Ultrasound Obstet Gynecol 26(4): 348.

2004

Aida, K., Shi, Q., Wang, J., VandeBerg, J.L., McDonald, T., Nathanielsz, P.W., Wang, X.L. (2004) The effects of betamethasone (BM) on endothelial nitric oxide synthase (eNOS) expression in adult baboon femoral arterial endothelial cells. Steroids 91(4-5): 219-24.

Aida, K., Wang, X.L., Wang, J., Li, C., McDonald, T.J., Nathanielsz, P.W. (2004) Effect of betamethasone administration to the pregnant baboon at 0.75 gestation on placental eNOS distribution and activity. Placenta 25(10): 780-7.

Frost, P.A., Hubbard, G.B., Dammann, M.J., Snider, C.L., Moore, C.M., Hodara, V.L., Giavedoni, L.D., Rohwer, R., Mahaney, M.C., Butler, T.M., Cummins, L.B., McDonald, T.J., Nathanielsz, P.W., Schlabritz-Loutsevitch, N.E. (2004) White monkey syndrome in infant baboons (Papio species). J Med Primatol 33(4): 197-213.

Giavedoni LD, Schlabritz-Loutsevitch N, Hodara VL, Parodi LM, Hubbard GB, Dudley DJ, McDonald TJ, Nathanielsz PW. (2004) Phenotypic changes associated with advancing gestation in maternal and fetal baboon lymphocytes. J Reprod Immunol 64(1-2): 121-32.

Nathanielsz, P.W., Howell, K., Glover, E.J., Nevill, C.H., Jenkins, S.L., Hubbard, G., McDonald, T.J., Schlabritz-Loutsevitch, N.E. (2004) The use of female baboon to study nutrition influences of pregnancy. Tardif, S. and VandeBerg, J., eds.

Nathanielsz, P.W., Smith, G., Wu, W. (2004) Topographical specialization of prostaglandin function in late pregnancy and at parturition in baboons. Prostaglandin Leukot Essent Fatty Acids 70(2): 199-206.

Schlabritz-Loutsevitch, N.E., Howell, K., Rice, K., Glover, E.J., Nevill, C.H., Jenkins, S.L., Cummins, L.B., Frost, P.A., McDonald, T.J., Nathanielsz, P.W. (2004) Development of a system for individual feeding of baboons maintained in a group social environment. J Med Primatol 33:1-10.

Schlabritz-Loutsevitch, N., Hubbard, G.B., Dammann, M.J., Jenkins, S.L., Frost, P.A., McDonald, T.J., Nathanielsz, P.W. (2004) Normal concentrations of essential and toxic elements in pregnant baboons and fetuses (Papio species). J Med Primatol 33(3):152-62.

Schlabritz-Loutsevitch, N.E., Hubbard, G.B., Frost, P.A., Cummins, L.B., Dick, E.J., Jr., Nathanielsz, P.W., McDonald, T.J. (2004) Abdominal pregnancy in a baboon: a first case report. J Med Primatol 33(1): 55-59.

Wu WX, Smith GC, Rose J, Nathanielsz PW. (2004) Characterization of the concentration gradient of prostaglandin H synthase 2 mRNA throughout the pregnant baboon uterus. J. Endocrinol 182(2): 241-248.

2003

Antonow-Schlorke I, Schwab M., Li, C., Nathanielsz, P.W. (2003) Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J Physiol 547(1): 117-123.

Chao, A.C., Ziadeh, B.I., Diau, G.Y., Wijendran,V., Sarkadi-Nagy, E., Hsieh, A.T., Nathanielsz, P.W., Brenna, J.T. (2003) Influence of dietary long-chain PUFA on premature baboon lung FA and dipalmitoyl PC composition. Lipids 38(4): 425-429.

Diau, G.Y., Loew, E.R., Wijendran, V., Sarkadi-Nagy, E., Nathanielsz, P.W. (2003) Docosahexaenoic and arachidonic acid influence on preterm baboon retinal composition and function. Invest.Ophthalmo Vis Sci 44(10): 4559-4566.

Diau, G.Y., Loew, E.R., Wijendran, V., Sarkadi-Nagy, E., Nathanielsz, P.W., Brenna, J.T. (2003) Docosahexaenoic and arachidonic acid influence on preterm baboon retinal composition and function. Invest. OphthalmolVis Sci 44(10): 4559-4566.

Ma. X.H., Wu, W.X., Nathanielsz, P.W. (2003) Gestation-related and betamethasone-induced changes in 11beta-hydroxysteroid dehydrogenase types 1 and 2 in the baboon placenta. Am J Obstet Gynecol 188(1): 13-21.

Sarkadi-Nagy, E., Wijendran, V., Diau, G.Y., Chao, A.C., Hsieh, A.T., Purpeinen, A., Lawruence, P., Nathanielsz, P.W., Brenna, J.T. (2003) Formula-feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm babon neonates. J Lipid Res 45: 71-80.

Sarkadi-Nagy,E., Wijendran,W., Diau, G.Y., Chao, A.C., Hsieh, A.T., Turpeinen, A., Nathanielsz, P.W. (2003) The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. Pediatr Res 54(2): 244-252.

2002

Bievenue, A, Jenkins, S.L., Nathanielsz, P.W. (2002) The effects of photoperiod on the switching of myometrial contractility patterns of pregnant baboons: relationship to surgery and parturition. J Soc Gyn Invest 9(1): 27-31.

Koenen SV, Mecenas CA, Smith GS, Jenkins S, Nathanielsz PW. Effects of maternal betamethasone administration on fetal and maternal blood pressure and heart rate in the baboon at 0.7 of gestation. Am J Obstet Gynecol 186(4): 812-7.

Wijendran, V., Huang, MC, Diau, G.Y., Boehm, G., Nathanielsz, P.W., Brenna, J.T. (2002) Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates. Pediatr Res 51(3): 265-72.

Wijendran V, Lawrence, P., Diau GY, Boehm G, Nathanielsz PW, Brenna JT. (2002) Significant utilization of dietary arachidonic acid is for brain adrenic acid in baboon neonates. J Lipid Res 43(5): 762-7.

2001

Anwar, M.A. Ju, K., Docherty, C.C. Poston, L., Nathanielsz, P.W. (2001) Developmental changes in reactivity of small femoral arteries in the fetal and postnatal baboon. Am J Obstet Gynecol 184(4): 707-12.

Mirmiran, M., Bernardo, L., Jenkins, S.L., Ma, X.H., Brenna, J.T., Nathanielsz, P.W. (2001) Growth, neurobehavioral and circadian rhythm development in newborn baboons. Pediatr Res 49(5): 673-7.

Smith, G.C.S., Wu, W.X., Nathanielsz, P.W. (2001) Effects of gestational age and labor on the expression of prostanoid receptor genes in pregnant baboon cervix. Prostaglandins 63(4): 153-163.

Smith, G.C.S., Wu, W.X., Nathanielsz, P.W. (2001) Lipoxygenase gene expression in baboon intrauterine tissues in late pregnancy and parturition. Mol Hum Reprod 7(6): 587-94.

Smith, G.C.S., Wu, W.X., Nathanielsz, P.W. (2001) Effects of gestational age and labor on expression of prostanoid receptor genes in baboon uterus. Biol Reprod 64(4): 1131-7.

Smith, G.C.S., Wu, W.X., Nathanielsz, P.W. (2001) Expression of prostanoid receptor genes in baboon chorion and decidua during pregnancy and parturition. J.Endocrinol 168(2): 263-72.

Su, H.M., Huang, M.C., Saad, N.M., Nathanielsz, P.W., Brenna, J.T. (2001) Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. J Lipid Res 42(4): 581-586.

Wu, W.X., Ma XH, Zhang Q, Nathanielsz PW. (2001) Characterization of topology , gestation and labor related changes of a cassette of myometrial ontraction associated protein mRNA in the pregnant baboon myometrium. J Endocrinol 171(3): 445-53.

2000

Baguma-Nibasheka, M., Mecenas, C.A., Giussani, D.A., Tame, J.D., Nathanielsz, P.W. (2000) Inhibitory effect of iloprost on the contractility of lower uterine segment myometrium from rhesus monkeys in normal term and androstenedione induced preterm labor. J Soc Gyn Invest 7(3): 167-9.

Giussani, D.A., Farber, D.M., Jenkins, S.L., Yen, A., Winter, J.A., Tame, J.D., Nathanielsz, P.W. (2000) Opposing effects of androgen and estrogen on pituitary-adrenal function in the nonpregnant baboon. Biol Reprod 62(5): 1445-1451.

Giussani, D.A., Jenkins, S.L., Winter, J.A., Tame, J.D., Nathanielsz, P.W. (2000) Androstenedione treatment of pregnant baboon at 0.7-0.8 of gestation promotes a premature forward shift in the nocturnal maternal plasma estradiol surge relative to progesterone and increased myometrial contraction activity. Endocrinology 141(9): 3296-3302.

Wu, W.X., Ma, X.H., Smith, G.C., Koenen, S.V., Nathanielsz P.W. (2000) A new concept of the significance of regional distribution of prostaglandin H synthase 2 throughout the uterus during late pregnancy: investigations in a baboon model. Am J Obstet Gynecol 183(5): 1287-95.

Wu, W.X., Ma, X.H., Smith, G.C.S., Mecenas, C.A., Koenen, S.V., Nathanielsz, P.W. (2000) Prostaglandin dehydrogenase mRNA in baboon intrauterine tissues in late gestation and spontaneous labor. Am. J. Physiol: Regulatory, Integrative and Comparative Physiol 279(3): R1082-90

Wu, W.X., Ma, X.H., Smith, G.C.S., Nathanielsz, P.W. (2000) Differential distribution of Erα and Erβ mRNA in intrauterine tissue of the pregnant rhesus monkey. Am J Physiol Cell Physiol 278: C190-C198.

1999

Giussani, D.A., Nathanielsz, P.W. (1999) Feedback regulation of androgens and oestrogens in primate pregnancy. 7th International Course on Recent Advances in Perinatal Medicine, Erice (Sicily), Italy.

Nathanielsz, P.W. (1999) How far upstream or downstream is corticotropin-releasing hormone in the overall process of parturition in rhesus monkeys? Am J Obstet Gynecol. 180: S267-268.

Su, H.M., Bernardo, L., Mirmiran, M., Ma, X.H., Corso, T.N., Nathanielsz, P.W., Brenna, J.T. (1999) Bioequivalence of dietary alpha linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. Pediatr Res 45(1): 87-93.

Su, H.M., Bernardo, L., Mirmiran, M., Ma, X.H., Nathanielsz, P.W., Brenna, J.T. (1999) Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids 34: S347-350.

Su, H.M., Corso, T.N., Nathanielsz, P.W., Brenna, J.T. (1999) Linoleic acid kinetics and conversion to arachidonic acid in the pregnant and fetal baboon. J Lipid Research 40(7): 1304-12.

Tame, J.D., Abrams, L.M., Ding, X-Y., Yen, A., Giussani, D.A., Nathanielsz, P.W. (1999) The level of post-surgical analgesia is a critical factor in regulating myometrial contractility following laparotomy in the pregnant baboon: Implications for human fetal surgery. Am J Obstet Gynecol180: 1196-1201

Zogopoulos, G., Nathanielsz, P.W., Hendy, G.N., Goodyer, C.G. (1999) The baboon: A model for the study of primate growth hormone receptor gene expression during development. J Molecular Endo 23: 67-75.

1998

Giussani, D.A., Winter, J.A., Jenkins, S.L., Tame, J.D., Abrams, L.M. , Ding, X.-Y, Nathanielsz, P.W. (1998) Changes in fetal plasma corticotropin-releasing hormone during androstenedione-induced labor in the rhesus monkey: Lack of an effect on the fetal hypothalamo-pituitary-adrenal axis. Endocrinology 139: 2803-2810.

Nathanielsz, P.W., Jenkins, S.L., Tame, J.D., Winter, J.A., Guller, S., Giussani, D.A. (1998) Local and paracrine effects of estradiol are central to parturition in the rhesus monkey. Nature Medicine 4(4): 456-459.

Pitera, A.E., Smith, G.C., Wentworth, R.A., Nathanielsz, P.W. (1998) Parathyroid hormone related peptide (1-34) (PTHrP) inhibits in vitro oxytocin stimulated activity of pregnant baboon myometrium. Am J Obstet Gynecol 179:492-496.

Smith, G.C.S., Baguma-Nibasheka, M., Wu, W.X., Nathanielsz, P.W. (1998) Regional variation in contractile responses to prostaglandin and prostanoid receptors messenger ribonucleic acid in pregnant baboon uterus. Am J Obstet Gynecol 179:1545-1552.

Tame, J.D., Winter, J.A., Li, C., Jenkins, S.L., Giussani, D.A., Nathanielsz, P.W. (1998) Fetal growth in the baboon during the second half of pregnancy. J Med Primatol 27(5) 234-239.

1997

Farber, D.M., Giussani, D.A., Jenkins, S.L., Mecenas, C.A., Winter, J.A., Wentworth, R.A., Nathanielsz, P.W. (1997) Timing of the switch from myometrial contractures to contractions in late gestation pregnant rhesus monkeys recorded by myometrial electromyogram during spontaneous term and androstenedione-induced labor. Biol Reprod 56: 557-562.

Giussani, D.A., Parks, J.E., Hough, S.R., Jenkins, S.L., Winter, J.A., Nathanielsz, P.W. (1997) Relationship between androstenedione-induced myometrial contractions and platelet-activating factor acetylhydrolase in late gestation in pregnant rhesus monkeys. Biol Reprod 56: 247-252.

Nathanielsz, P.W., Honnebier, M.B.O.M., Mecenas, C., Jenkins, S.L., Holland, M.L., Demarest, K. (1997) The effect of the oxytocin antagonist Atosiban (1-deamino-2-D-tyr(OET)4-thr-8-orn-vasotocin/oxytocin) on myometrial contractility, maternal cardiovascular function, transplacental passage, and fetal oxygenation in the pregnant baboon during the last third of gestation. Biol Reprod 57: 320-324.

Ramsay, M.M., Tame, J.D., Winter, J.A., Carbone, L.G., Schlafer, D.AH., Nathanielsz, P.W. (1997) Proteinuric hypertension in a pregnant baboon: Was this pre-eclampsia? J Med Primatol 26: 207-212.

Wandji, S.-A., Srsen, V., Nathanielsz, P.W., Eppig, J.J., Fortune, J.E. (1997) Initiation of growth of primate primordial follicles in vitro. Human Reprod 12(9): 1993-2001.

Zhang, Q., Wu, W.X., Ma., X.H., Nathanielsz, P.W., Brenna, J.T. (1997) Pulmonary phospholipid saturation increases with glucocorticoid receptor mRNA in late gestation but not due to labor in the fetal rhesus monkey. Prostaglandins, Leukotrienes, and Essential Fatty Acids 57(3): 311-321.

1996

Giussani, D.A., Jenkins, S.L., Mecenas, C.A., Winter, J., Derks, J.B., Baguma-Nibasheka, M., Honnebier, M.B.O.M., Nathanielsz, P.W. (1996) The oxytocin antagonist Atosiban prevents Δ4Androstenedione-induced, prematurely occurring and spontaneous term myometrial contractions in the chronically-instrumented rhesus monkey. Endocrinology 137: 3302-3307.

Giussani, D.A., Jenkins, S.L., Mecenas, C.A., Winter, J., Honnebier, M.B.O.M., Wu, W.X., Owiny, J., Nathanielsz, P.W. (1996) Daily and hourly temporal association between -4Androstenedione-induced, pre-term myometrial concentrations and maternal plasma estradiol and oxytocin concentrations in the 0.8 gestation rhesus monkey. Am J Obstet Gynecol 174(3): 1050-1055.

Giussani, D.A., Jenkins, S.L., Mecenas, C.A., Winter, J.A., Pedro, J.G., Farber, D.M., Goland, R.S., Nathanielsz, P.W. (1996) Effect of androstenedione administration on the maternal hypothalamo-pituitary-adreno-placental axis in the pregnant rhesus monkey. Endocrinology 137: 608-614.

Mecenas, C.A., Giussani, D.A., Owiny, J.R., Jenkins, S.L., Wu, W.X., Honnebier, M.B.O.M., Lockwood, C.J., Kong, L., Guller, S., Nathanielsz, P.W. (1996) Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nature Medicine 2(4): 443-448.

Morgan, M.A., Honnebier, M.B.O.M., Mecenas, C., Nathanielsz, P.W. (1996) Cocaine’s effect on plasma oxytocin concentrations in the baboon during late pregnancy. Am J Obstet Gynecol 174: 1026-1027.

Sheaff, R.C., Zhang, Q, Goodman, K.J., Giussani, D., Nathanielsz, P.W., Brenna, J.T. (1996) α-Linolenate and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in the pregnant, lactating, fetal and infant rhesus monkey. J Lipid Research 37: 2675-2686.

1995

Wu, S.S., Nathanielsz, P.W., McDonald, T.J. (1995) Immunocytochemical distribution of androgen receptors in the hypothalamus and pituitary of the fetal baboon in late gestation. Developmental Brain Research 84:278-281.

Wu, W.X., Unno, S., Giussani, D.A., Mecenas, C.A., McDonald, T.J., Nathanielsz, P.W. (1995) Corticotropin-releasing hormone and its receptor distribution in the fetal membranes and placenta of the rhesus monkey in late gestation and labor. Endocrinology 136: 4621-4628.

 

sheep_silhouette

Sheep Investigations

2016

Dreiling, M., Bischoff, S., Schiffner, R., Rupprecht, S., Kiehntopf, M., Schubert, H., Witte, O.W., Nathanielsz, P.W., Schwab, M., Rakers, F. (2016) Stress-induced decrease of uterine blood flow in sheep is mediated by alpha 1-adrenergic receptors. Stress 19:547–551. PMID 27352901.

2015

Long, N. M., Rule, D. C., Tuersunjiang, N., Nathanielsz, P. W., & Ford, S. P. (2015) Maternal obesity in sheep increases fatty acid synthesis, upregulates nutrient transporters, and increases adiposity in adult male offspring after a feeding challenge. PloS One 10(4): e0122152. PMID 25875659.

Rakers, F., Bischoff, S., Schiffner, R., Haase, M., Rupprecht, S., Kiehntopf, M., Kühn-Velten, W. N., Schubert, H., Witte, O.W., Nijland, M.J., Nathanielsz, P.W., Schwab, M. (2015) Role of catecholamines in maternal-fetal stress transfer in sheep. Am J Obstet Gynecol 213(5):684.e1-e9. PMID 26212181.

Shasa, D. R., Odhiambo, J. F., Long, N. M., Tuersunjiang, N., Nathanielsz, P. W., & Ford, S. P. (2015) Multigenerational impact of maternal overnutrition/obesity in the sheep on the neonatal leptin surge in granddaughters. Int J Obes (Lond) 39(4): 695–701. PMID 25354845.

2013

Ge, W., Hu, N., George, L. A., Ford, S. P., Nathanielsz, P. W., Wang, X.-M., & Ren, J. (2013) Maternal nutrient restriction predisposes ventricular remodeling in adult sheep offspring. J Nutr Biochem 24(7): 1258–1265. PMID 23333094.

Kandadi, M. R., Hua, Y., Zhu, M., Turdi, S., Nathanielsz, P. W., Ford, S. P., Nair, S., Ren, J. (2013) Influence of gestational overfeeding on myocardial proinflammatory mediators in fetal sheep heart. J Nutr Biochem 24(11): 1982–1990. PMID 24075902.

Long, N. M., Smith, D. T., Ford, S. P., & Nathanielsz, P. W. (2013) Elevated glucocorticoids during ovine pregnancy increase appetite and produce glucose dysregulation and adiposity in their granddaughters in response to ad libitum feeding at 1 year of age. Am J Obstet Gynecol 209(4): 353.e1–353.e9. PMID 23727517.

Long, N. M., Tuersunjiang, N., George, L. A., Lemley, C. O., Ma, Y., Murdoch, W. J., Nathanielsz, P. W., Ford, S. P. (2013) Maternal nutrient restriction in the ewe from early to midgestation programs reduced steroidogenic enzyme expression and tended to reduce progesterone content of corpora lutea, as well as circulating progesterone in nonpregnant aged female offspring. Reprod Biol Endocrinol 11: 34. PMID 23656912.

Tuersunjiang, N., Odhiambo, J. F., Long, N. M., Shasa, D. R., Nathanielsz, P. W., & Ford, S. P. (2013) Diet reduction to requirements in obese/overfed ewes from early gestation prevents glucose/insulin dysregulation and returns fetal adiposity and organ development to control levels. Am J Physiol Endocrinol Metab 305(7): E868–878. PMID 23921140.

2012

Cox, L.A., Glenn, J.P., Spradling, K.D., Nijland, M.J., Garcia, R., Nathanielsz, P.W., Ford, S.P. (2012) A genome resource to address mechanisms of developmental programming; determination of the fetal sheep heart transcriptome. J Physiol 590: 2873-2884.

George, L.A., Zhang, L., Tuersunjiang, N., Ma, Y., Long, N.M., Uthlaut, A.B., Smith, D.T., Nathanielsz, P.W., Ford, S.P. (2012) Early maternal undernutrition programs increased feed intake, altered glucose metabolism and insulin secretion, and liver function, in aged female offspring. Am J Physiol Regul Integr Comp Physiol 302: R795-R804.

Huang, Y., Zhao, J.X., Yan, X., Zhu, M.J., Long, N.M., McCormick, R.J., Ford, S.P., Nathanielsz, P.W., Du, M. (2012) Maternal obesity enhances collagen accumulation and cross-linking in skeletal muscle of ovine offspring. PLoS One 7: e31691.

Long, N., Ford, S., Nathanielsz, P. (2012) Multigenerational effects of fetal dexamethasone exposure on the hypothalamic-pituitary-adrenal axis of first and second generation female offspring. AJOG 208(3): 217. PMID 23220271.

Long, N.M., Nathanielsz, P.W., Ford, S.P. (2012) The impact of maternal overnutrition and obesity on hypothalamic-pituitary-adrenal axis response of offspring to stress. Domest Anim Endocrinol 42(4): 195–202.

Long, N.M., Rule, D.C., Zhu, M.J., Nathanielsz, P.W., Ford, S.P. (2012) Maternal obesity upregulates fatty acid and glucose transporters and increases expression of enzymes mediating fatty acid biosynthesis in fetal adipose tissue depots. J Anim Sci 90(7): 2201-2210.

Long, N.M., Shasa, D.R., Ford, S.P. and Nathanielsz, P.W. (2012) Growth and insulin dynamics in two generations of female offspring of mothers receiving a single course of synthetic glucocorticoids. Am J Obstet Gynecol 207: 203.e1-203.e8.

Yan, X., Huang, Y., Zhao, J.X., Rogers, C.J., Zhu, M.J., Ford, S.P., Nathanielsz, P.W., Du, M. (2012) Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development. Int J Obes (Lond) 37(4): 568-575.

2011

Breton AB, Cockrum RR, Austin KJ, Cammack KM, Ford SP, Hess BW, Moss GE, Nathanielsz PW, Alexander BM (2011) Hypothalamic expression of genes for appetite regulators and estrogen α, estrogen β and leptin receptors in obese dams and their fetuses. Animal 5(12): 1944-1948.

Long NM, Ford SP, Nathanielsz PW. (2011) Maternal obesity eliminates the neonatal lamb plasma leptin peak. J Physiol 589(6): 1455–1462. PMID 21262878.

Ma Y, Zhu MJ, Uthlaut AB, Nijland MJ, Nathanielsz PW, Hess BW, Ford SP (2011) Upregulation of growth signaling and nutrient transporters in cotyledons of early to mid-gestational nutrient restricted ewes. Placenta 32(3): 255–263. PMID 21292322.

Yan X, Huang Y, Wang H, Du M, Hess BW, Ford SP, Nathanielsz PW, Zhu MJ. (2011) Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep. Inflamm Bowel Dis 17(7): 1513-22. PMID 21674707.

Yan, X, Huang Y, Zhao JX, Long NM, Uthlaut AB, Zhu MJ, Ford SP, Nathanielsz PW, Du M (2011) Maternal Obesity-Impaired Insulin Signaling in Sheep and Induced Lipid Accumulation and Fibrosis in Skeletal Muscle of Offspring. Biol Reprod 85(1): 172-178. PMID 21349823.

Zhang L, Long NM, Hein SM, Ma Y, Nathanielsz PW, Ford SP. (2011) Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term. Domest Anim Endocrinol 40(1): 30-9. PMID 20933362.

2010

Du M, Tong J, Zhao J, Underwood KR, Zhu M, Ford SP, Nathanielsz PW (2010) Fetal Programming of Skeletal Muscle Development in Ruminant Animals. J Anim Sci 88(13 Suppl): E51-60.

Fan X, Turdi S, Ford SP, Hua Y, Nijland MJ, Zhu M, Nathanielsz PW, Ren J (2010) Influence of gestational overfeeding on cardiac morphometry and hypertrophic protein markers in fetal sheep. J Nutr Biochem 22(1): 30-37. PMID 20188535.

George LA, Uthlaut AB, Long NM, Zhang L, Ma Y, Smith DT, Nathanielsz PW, Ford SP (2010) Different levels of overnutrition and weight gain during pregnancy have differential effects on fetal growth and organ development. Reprod Biol Endocrinol 8: 75. PMID 20576133.

Huang Y, Yan X, Zhao JX, Zhu MJ, McCormick RJ, Ford SP, Nathanielsz PW, Ren J, Du M. (2010) Maternal obesity induces fibrosis in fetal myocardium of sheep. Am J Physiol Endocrinol Metab 299(6): E968-75. PMID 20876759.

Huang Y, Yan X, Zhu MJ, McCormick RJ, Ford SP, Nathanielsz PW, Du M. (2010) Enhanced transforming growth factor β (TGF-β) signaling and fibrogenesis in ovine fetal skeletal muscle of obese dams at late gestation. Am J Physiol Endocrinol Metab 298(6): E1254-60. PMID 20371734.

Loehle M, Schwab M, Kadner S, Maner KM, Gilbert JS, Brenna JT, Ford SP, Nathanielsz PW, Nijland MJ (2010) Dose-response effects of betamethasone on maturation of the fetal sheep lung. Am J Obstet Gynecol 202(2): 186.e1-7. PMID 20022315.

Long NM, George LA, Uthlaut AB, Smith DT, Nijland MJ, Nathanielsz PW, Ford SP. (2010) Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity and glucose tolerance in adult offspring. J Anim Sci 88(11): 3546-53. PMID 20622177.

Long NM, Nijland MJ, Nathanielsz, PW, Ford SP (2010) The impact of early to mid-gestational nutrient restriction on female offspring fertility and hypothalamic-pituitary-adrenal axis response to stress. J Anim Sci 88(6): 2029-2037. PMID 20190172

Ma Y, Zhu MJ, Zhang L, Hein SM, Nathanielsz PW, Ford SP. (2010) Maternal obesity and overnutrition alters fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe. Am J Physiol Regul Integr Comp Physiol 299(1): R249-R258. PMID 20427725.

Wang J, Ma H, Tong C, Zhang H, Lawlis GB, Li Y, Zang M, Ren J, Nijland MJ, Ford SP, Nathanielsz PW, Li J. (2010) Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart. FASEB J 450(1-2): 1-7. PMID 20110268.

Yan X, Zhu MJ, Xu W, Tong JF, Ford SP, Nathanielsz PW, Du M (2010) Up-regulation of Toll-like receptor 4/nuclear factor-kappaB signaling is associated with enhanced adipogenesis and insulin resistance in fetal skeletal muscle of obese sheep at late gestation. Endocrinology 151(1): 380-7.

Zhu MJ, Du M, Nathanielsz PW, Ford SP (2010) Maternal obesity up-regulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta. Placenta 31(5): 387-91. PMID 20185176.

2009

Alexander, B.M., Singh, P., Austin, K.J., Cockrum, R.R., Cammack, K.M., Hess, B.W., Moss, G.E., Nathanielsz, P.W., Ford, S.P. (2009) Effect of maternal fatness on fetal steroids and semi-quantitative real-time PCR expression of receptor genes in sheep. Anim Reprod Sci 116(1-2): 58–64.

Antonow-Schlorke, I., Helgert, A., Gey, C., Coksaygan, T., Schubert, H., Nathanielsz, P.W., Witte, O.W., Schwab, M. (2009) Adverse effects of antenatal glucocorticoids on cerebral myelination in sheep. Obstet Gynecol 113(1): 142-151.

Long NM, Vonnahme KA, Hess BW, Nathanielsz PW, Ford SP (2009) Effects of early gestational undernutrition on fetal growth, organ development, and placentomal composition in the bovine. J Anim Sci 87(6): 1950-9.

Ford SP, Zhang, L, Zhu M, Miller MM, Smith DT, Hess BW, Moss GE, Nathanielsz PW, Nijland MJ (2009) Maternal obesity accelerates fetal pancreatic beta-cell but not alpha-cell development in sheep: prenatal consequences. Am J Physiol Regul Integr Comp Physiol 297(3): R835-43.

Zhu MJ, Du M, Nijland MJ, Nathanielsz PW, Hess BW, Moss GE, Ford SP (2009) Down-regulation of growth signaling pathways linked to a reduced cotyledonary vascularity in placentomes of over-nourished, obese pregnant ewes. Placenta 30(5): 405-10.

2008

Dong, F., Ford, S.P., Nijland, M.J., Nathanielsz, P.W., Ren, J. (2008) Influence of maternal undernutrition and overfeeding on cardiac ciliary neurotrophic factor receptor and ventricular size in fetal sheep. J Nutr Biochem 19(6): 409–414.

Hsieh, A.T., Anthony, J.C., Diersen-Schade, D.A., Nathanielsz, P.W., Brenna, J.T. (2008) Biochemical and white blood cell profiles of baboon neonates consuming formulas with moderate and high dietary long-chain polyunsaturated fatty acids. J Med Primatol 37(2): 81-87.

McCallum J, Smith N, Schwab M, Coksaygan T, Reinhardt B, Nathanielsz P, Richardson BS (2008) Effects of antenatal glucocorticoids on cerebral protein synthesis in the preterm ovine fetus. Am J Obstet Gynecol 198(1): 103.e1-6.

McCallum J, Smith N, Schwab M, Coksaygan T, Reinhardt B, Nathanielsz P, Richardson BS. (2008) Effects of antenatal glucocorticoids on cerebral substrate metabolism in the preterm ovine fetus. Am J Obstet Gynecol 198(1): 105E1-9.

Zhou, Y., Nijland, M., Miller, M., Ford, S., Nathanielsz, P.W., Brenna, J.T. (2008) The influence of maternal early to mid-gestation nutrient restriction on long chain polyunsaturated fatty acids in fetal sheep. Lipids 43(6): 523-531.

Zhu, M.J., Han, B., Tong, J., Ma, C., Kimzey, J.M., Underwood, K.R., Xiao, Y., Hess, B.W., Ford, S.P., Nathanielsz, P.W., Du, M. (2008) AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. J Physiol 586(2): 2651:2664.

2007

Antonow-Schlorke, I., Muller, T., Brodhun, M., Wicher, C., Schubert, H., Nathanielsz, P.W., Witte, O.W., Schwab, M. (2007) Betamethasone-related acute alterations of microtubule-associated proteins in the fetal sheep brain are reversible and independent of age during the last one-third of gestation. Am J Obstet Gynecol 196(6): 553.e1-6.

Burt, BE, Hess BW, Nathanielsz PW, Ford SP. (2007) Flock differences in the impact of maternal dietary restriction on offspring growth and glucose tolerance in female offspring. Soc Reprod Fertil Suppl 64: 411-424.

Ford, S.P., Hess, B.W., Schwope, M.M., Nijland, M.J., Gilbert, J.S., Vonnahme, K.A., Means, W.J., Han, H., Nathanielsz, P.W. (2007). Maternal undernutrition during early to mid-getstation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring. J Anim Sci 85(5): 1285-1294.

Frasch, M.G., Muller, T., Wicher, C., Weiss, C., Lohle, M., Schwab, K., Schubert, H., Nathanielsz, P.W., Witte, W., Schwab, M. (2007) Fetal body weight and the development of the control of the carvascular system in the sheep. J Physiol 579: 893-907.

Gilbert, J.S., Ford, S.P., Lang, A.L., Pahl, L.R., Drumhiller, M.C., Babcock, S.A., Nathanielsz, P.W., Nijland, M.J. (2007) Nutrient restriction impairs nephrogenesis in a gender-specific manner in the ovine fetus. Pediatric Res (61)1: 1-3.

Jobgen, W.S., Ford, S.P., Jobgen, S.C., Feng, C.P. Hess, B.W., Nathanielsz, P.W., Li, P., Wu, G. (2007) Baggs ewes adapt to maternal undernutrition and maintain conceptus growth by maintaining fetal plasma concentrations of amino acids. J Anim Sci 86(4): 820-826.

Zhu, M.J., Du, M., Hess, B.W., Means, W.J., Nathanielsz, P.W., Ford, S.P. (2007) Maternal nutrient restriction upregulates growth signaling pathways in the cotyledonary artery of cow placentomes. Placenta 28(4): 361-8.

Zhu, M.J., Du, M., Hess, B.W., Nathanielsz, P.W., Ford, S.P. (2007) Periconceptional nutrient restriction in the ewe alters MAPK/ERK1/2 and P13K/Akt growth signaling pathways and vacularity in the placentome. Placenta 28(11-12): 1192-1199.

2006

Antonow-Schlorke, I., Ebert, M., Muller, T., Schubert, H., Gschanes, A., Witte, O.W. Nathanielsz, P.W., Schwab, M. (2006) Glucose transporter proteins GLUT1 and GLUT3 like immunoractivities in the fetal sheep brain are not reduced by maternal betamethasone treatment. Neurosci Lett 403(3): 261-265.

Schmitz, T., Levine, B.A., Nathanielsz, P.W. (2006) Localization and steroid regulation of prostaglandin E2 receptor protein expression in ovine cervix. Reproduction 131(4): 743-50.

Schwab, M., Coksaygan, T., Nathanielsz, P.W. (2006) Betamethasone effects on ovine uterine and umbilical placental perfusion at the dose used to enhance fetal lung maturation. Am J Obstet Gynecol 194(2): 572-579.

Schwab, M., Coksaygan, T., Samtani, M.N., Jusko, W.J., Nathanielsz, P.W. (2006) Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses. Obstet Gynecol 108(2): 617-625.

Vonnahme, K.A., Hess, B.W., Nijland, M.J., Nathanielsz, P.W., Ford, S.P. (2006) Placentomal differentiation may compensate for maternal nutrient restriction in ewes adapted to harsh ange conditions. J Anim Sci 84(12): 3451-3459.

Zhu, M.J., Ford, S.P., Means, W.J., Hess, B.W., Nathanielsz, P.W., Du, M. (2006) Maternal nutrient restriction affects properties of skeletal muscle in offspring. J Physiol 575(1): 241-250.

2005

Dong, F., Ford, S.P., Fang, C.X., Nijland, M.J., Nathanielsz, P.W., Ren, J. (2005) Maternal nutrient restriction during early to mid gestation up-regulates cardiac insulin-like growth factor (IGF) receptors associated with enlarged ventricular size in fetal sheep. Growth Horm & IGF Res 15(4): 291-299.

Fletcher, A.J.W., Forhead, A.J., Fowden, A.L., Ford, W.R., Nathanielsz, P.W., Giussani, D.A. (2005) Effects of gestational age and cortisol treatment on ovine fetal heart function in a novel biventricular Langeldorff preparation. J Physiol 562(Pt 2): 493-505

Lohle M, Muller T, Wicher C, Roedel M, Schubert H, Witte OW, Nathanielsz PW, Schwab M. (2005) Betamethasone effects on fetal sheep cerebral blood flow are not dependent on maturation of cerebrovascular system and pituitary-adrenal axis. J Physiol 564: 575-588.

Samtani MN, Lohle M, Grant A, Nathanielsz PW, Jusko WJ. (2005) Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use. Drug Metab Dispos 33(8): 1124-1130.

Wu WX, Coksaygan T, Chakrabarty K, Collins V, Rose JC, Nathanielsz PW. (2005) Sufficient Progesterone-priming Prior to Estradiol Stimulation Is Required for Optimal Induction of the Cervical Prostaglandin System in Pregnant Sheep at 0.7 Gestations. Biol Reprod 73(2): 343-350.

Wu WX, Wolf R, Chakrabarty K, Collins V, Unno N, Nathanielsz PW, Rose JC. (2005) Induction of uterine prostaglandin H synthase 2 by estradiol following fetal adrenalectomy. Endocrine 26(2): 153-159.

2004

Fletcher A.J., Ma X.H., Wu, W.X., Nathanielsz P.W., McGarrigle H.H., Fowden A.L, Giussani D.A. (2004) Antenatal glucocorticoids reset the level of baseline and hypoxemia-induced pituitary-adrenal activity in the sheep fetus during late gestation. Am J Physiol Endocrinol Metab 286(2): E311-319.

Han HC, Austin KJ, Nathanielsz PW, Ford SP, Nijland MJ, Hansen TR. (2004) Maternal nutrient restriction alters gene expression in the ovine fetal heart. J Physiol 558: 111-121.

Kutzler, M.A., Coksaygan, T.C., Ferguson, A.D., Nathanielsz, P.W. (2004) Effects of maternally administered dexamethasone and acute hypoxemia at 0.7 gestation on blood pressure and placental perfusion in sheep. Hypertension in Pregnancy 23(1): 75-90.

Kutzler, M.A., Coksaygnan, T., Ferguson, A.D., Vincent, S.E., Nathanielsz, P.W. (2004) Maternally administered dexamethasone at 0.7 of gestation suppresses maternal and foetal pituitary and adrenal responses to hypoxaemia in sheep. Pediatr Res 55(5): 755-63.

Kutzler, M.A., Ruane, E.K., Coksaygan, T., Vincent, S.E., Nathanielsz, P.W. (2004) Effects of three courses of maternally administered dexamethasone at 0.7, 0.75, and 0.8 of gestation on prenatal and postnatal growth in sheep. Pediatrics 113(2): 313-319.

Kwon, H., Ford, S.P., Bazer, F.W., Spencer, T.E., Nathanielsz, P.W., Nijland, M.J., Hess, B.W., Wu, G. (2004) Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids. Biol Reprod 71(3): 901-908.

Samtani, M.N., Schwab, M., Nathanielsz, P.W., Jusko, W.J. (2004) Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. J Pharmaceutical Sci 93(3): 726-32.

Wu, W.X., Ma, X.H., Coksaygan, T., Chakrabarty, K., Collins, V., Rose, J., Nathanielsz, P.W. (2004) Prostaglandin mediates premature delivery in pregnant sheep induced by estradiol at 121 days of gestational age. Endocrionlogy 145(3): 1444-1452.

Zhu MJ, Ford SP, Nathanielsz PW, Du M. (2004) Effect of maternal nutrient restriction in sheep on the development of fetal skeletal muscle. Biol Reprod 71(6): 1968-1973

2003

Kutzler, M.A., Molnar, J., Schlafer, D.H., Kuc, R.E., Davenport, A.P., Nathanielsz, P.W. (2003) Maternal dexamethasone increases endothelin-1 sensitivty and endothelin A receptor expression in ovine foetal placental arteries. Placenta 24: 392-402.

Molnar, J., Howe, D.C., Nijland, M.J., Nathanielsz, P.W. (2003) Prenatal dexamethasone leads to both endothelial dysfunction and vasodilatory compensation in sheep. J Physiol 547(1): 61-66.

Vonnahme, K.A., Hess, B.W., Hansen, T.R., McCormick, R.J., Rule, D.C., Moss, G.E., Murdoch,W.J., Nijland, M.J., Skinner, D.C., Nathanielsz, P.W., Ford, S.P. (2003) Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertropy, and increased liver weight in the fetal sheep. Biol Reprod 69(1): 133-140.

Wu, W.X., Ma, X.H., Zhang, Q., Chakrabarty, K., Nathanielsz, P.W. (2003) Characterization of two labor-induced genes, DSCR1 and TCTE1L, in the pregnant ovine myometrium. J Endocrinol 178(1): 117-26.

2002

Molnar J, Nijland MJ, Howe DC, Nathanielsz PW. (2002) Evidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheep. Am J Physiol Regul Integr Comp Physiol 283(3): R561-7.

Muller, T., Lohle, M., Schubert, H., Bauer, R., Wicher, C., Antonow-Schlorke, I., Sliwka, U., Nathanielsz, P.W., Schwab, M. (2002) Developmental changes in cerebral autoregulatory capacity in the fetal sheep parietal cortex. J Physiol 539: 957-967.

Zambrano, E., Nathanielsz, P.W., McDonald (2002) Neonatal ovine adrenal cortical and medullary Cell H+ responses to ACTH and prostaglandin E(2). Biol Neonate 82(4): 243-9.

2001

Antonow-Schlorke, I., Kuhn, B., Muller, T., Schubert, H., Sliwka, U., Nathanielsz, P.W., Schwab, M. (2001) Antenatal betamethasone treatment reduces synaptophysin immunoreactivity in presynaptic terminals in the fetal sheep brain. Neurosci Let 297(3): 147-150

Docherty, C.C., Kalmar Nagy, J., Engelen, M., Koenen, S.V., Nijland, M., Kuc, R.E., Davenport, A.P., Nathanielsz, P.W. (2001) Effect of in vivo fetal infusion of dexamethasone at 0.75 GA on fetal ovine resistance artery responses to ET-1. Am J Physiol 281(1): R261-8.

Docherty CC, Kalmar Nagy J, Engelen M, Nathanielsz PW. (2001) Development of fetal vascular responses to endothelin 1 and acetylcholine in the sheep. Am J Physiol Regul Integr Comp Physiol 280(2): R554-62.

Moon, P.F., Bliss, S.P., Posner, L.P., Erb, H.N., Nathanielsz, P.W. (2001) Fetal oxygen content is restored after maternal hemorrhage and fluid replacement with polymerized bovine hemoglobin, but not with hetastarch, in pregnant sheep. Anesth Analg 93(1): 142-50.

Moon, P.F., Ramsay, M.M., Fecci, P.E., Nathanielsz, P.W. (2001) Fetal exposure to MgC12-ATP results in alterations in cerebral blood flow and a metabolic acidosis. Ped Crit Care Med 2(1): 74-81.

Schwab, M., Antonow-Schlorke, I., Kuhn, B., Muller, T., Schubert, H., Walter, B., Sliwka, U., Nathanielsz, P.W. (2001) Effect of antenatal betamethasone treatment on microtubule associated proteins MAP1B and MAP2 in fetal sheep. J Physiol 530(Pt 3): 497-506.

Wu, W.X., Ma, X.H., Unno, N., Nathanielsz, P.W. (2001) In vivo evidence for stimulation of placental, myometrial, and endometrial prostaglandin G/H synthase 2 by fetal cortisol replacement after fetal adrenalectomy. Endocrinology 142(5): 3857-3864.

Wu, W.X., Ma, X.H., Yoshizato, T., Shinozuka, N., Nathanielsz, P.W. (2001) Increase in prostaglandin H synthase 2, but not prostaglandin F2alpha synthase mRNA in intrauterine tissues during betamethasone induced premature labor and spontaneous term labor in sheep. JSGI 8(2) 69-76.

Zambrano, E., Nathanielsz, P.W., McDonald, T.J. (2001) Prenatal and postnatal ovine adrenal cell responses to prostaglandin E2. JSGI 8: 149-157.

2000

Coulter, C.L., Myers, D.A., Nathanielsz, P.W., Bird, I.M. (2000) Ontogeny of angiotensin II type 1 receptor (AT2R) and cytochrome P450c11 (CYP11B) in the sheep adrenal gland. Biol Reprod 62: 714-719.

Ma, X.H., Wu, W.X., Brenna, J.T., Nathanielsz, P.W. (2000) Maternal intravenous administration of polyunsaturated fatty acid to the pregnant ewe in late gestation results in specific inhibition of prostaglandin H synthase-2 but not oxytocin receptor mRNA in the pregnant sheep myometrium during betamethasone induced labor. J Soc Gynecol Invest 7(4): 233-237.

Schwab, M., Roedel, M., Anwar, M.A., Muller, T, Schubert, H., Buchwalder, L.F., Walter, B., Nathanielsz, P.W. (2000) Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol 528: 619-632.

Shinozuka, N., Yen, A., Nathanielsz, P.W. (2000) Increased myometrial contracture frequency at 96-140 days accelerates fetal cardiovascular maturation. Am J Physiol Heart Circ Physiol 278: H41-49.

Wu, W.X., Zhang, Q., Unno, N., Derks, J.B., Nathanielsz, P.W. (2000) Characterization of decorin mRNA in pregnant intrauterine tissue of the ewe and regulation by steroids. Am J Physiol Cell Physiol 278: C199-C206.

1999

Anwar, M.A., Poston, L., Docherty, C., Nathanielsz P.W. (1999) A comparative study of vascular responsiveness of myometrial and omental small resistance arteries in late gestation sheep. Am J Obstet Gynecol 181(3): 663-668.

Anwar, M.A., Schwab, M., Poston, L., Nathanielsz, P.W. (1999) Betamethasone mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am J Physiol 276: H1137-1143.

Baguma-Nibasheka, M., Brenna, J.T., Nathanielsz, P.W. (1999) Delay of preterm delivery in sheep by omega-3 long-chain polyunsaturates. Biol Reprod 60: 698-701.

Ma, X.H., Wu, W.X., Nathanielsz, P.W. (1999) Differential effects of natural and synthetic glucocorticoids on cytochrome 17α-hydroxylase (P45017α) and cytochrome P-450 side chain cleavage (P450scc) messenger ribonucleic acid in the sheep placenta. Am J Obstet Gynecol 180: 1215-1221.

Ma, X.H., Wu, W.X., Nathanielsz, P.W. (1999) Differential regulation of prostaglandin EP and FP receptors in pregnant sheep myometrium and endometrium during spontaneous term labor. Biol Reprod 61: 1281-1286.

Moon, P.F., Ramsay, M.M., Nathanielsz, P.W. (1999) Intravenous infusion of magnesium sulfate and regional redistribution of fetal blood flow during maternal hemorrhage in late gestation gravid ewes. Am J Obstet Gynecol 181(6): 1486-94.

Shinozuka, N., Yen, A., Nathanielsz, P.W. (1999) Alteration of fetal oxygenation and responses to acute hypoxemia by increased myometrial contracture frequency produced by pulse administration of oxytocin to the pregnant ewe from 96 to 131 days gestation. Am J Obstet Gynecol 180: 1202-1208.

Unno, N., Wong, C.H., Jenkins, S.L., Wentworth, R.A., Ding, X-Y., Li, C., Robertson, S.S., Smotherman, W.P., Nathanielsz, P.W. (1999) Blood pressure and heart rate in the ovine fetus: Ontogenic changes and effects of fetal adrenalectomy. Am J Physiol 276(1): H248-256.

Wu, W.X., Ma, X.H., Nathanielsz, P.W. (1999) Tissue-specific ontogenic expression of prostaglandin H synthase 2 in the ovine myometrium, endometrium, and placenta during late gestation and at spontaneous term labor. Am J Obstet Gynecol 181: 1512-1519.

Wu, W.X., Ma, X.H., Unno, N., Nathanielsz, P.W. (1999) Changes in prostacyclin synthase (PGIS) in pregnant sheep myometrium, endometrium, and placenta at spontaneous term labor and regulation by estradiol and progesterone. Am J Obstet Gynecol 180: 744-749.

Wu, W.X., Ma, X.H., Yoshizato, T., Shinozuka, N., Nathanielsz, P.W. (1999) Differential expression of myometrial oxytocin receptor and prostaglandin H synthase 2, but not estrogen receptor α and heat shock protein 90 messenger ribonucleic acid in the gravid horn and nongravid horn in sheep during betamethasone-induced labor. Endocrinology 140: 5712-5718.

Wu, W.X. Zhang, Q., Ma, X.H., Unno, N., Nathanielsz, P.W. (1999) Suppression subtractive hybridization identified a marked increase in thrombospondin-1 associated with parturition in pregnant sheep myometrium. Endocrinology 140: 2364-71.

1998

Anderson, C., Mandell, A., Selz, K., Terry, L., Wong, C., Robinson, S., Robertson, S., Nathanielsz, P.W., Smotherman, W. (1998) Invariant fractal time organization during development in REM sleep. Brain Res 787: 351-357.

Baguma-Nibasheka, M., Nathanielsz, P.W. (1998) In vivo administration of nimesulide, a selective PGHS-2 inhibitor, increases in vitro myometrial sensitivity to prostaglandins while lowering sensitivity to oxytocin. J Soc Gynecol Invest 5: 296-299.

Baguma-Nibasheka, M., Wentworth, R.A., Green, L.R., Jenkins, S.L., Nathanielsz, P.W. (1998) Differences in the in vitro sensitivity of ovine myometrium and mesometrium to oxytocin and prostaglandins E2 and F2α. Biol Reprod 58: 73-78.

Buchwalder, LF, Lin, M., McDonald, T.J., Nathanielsz, P.W. (1998) Fetal sheep adrenal blood flow responses to hypoxemia after splanchnicotomy using fluorescent microspheres. J Appl Physiol 84: 82-89.

Coulter, C.L., Myers, D.A., Nathanielsz, P.W., Bird, I.M. (1998) Ontogeny of angiotensin II type 1 receptor in the ovine adrenal gland. Endocrine Review 23(3/4): 935-936.

Shinozuka, N., Nathanielsz, P.W. (1998) Electrocortical activity in fetal sheep in the last seven days of gestation. J Physiol 513(1): 273-281.

Unno, N., Wu, W.X., Ding, X.Y., Li, C., Man A Hing, W.K.H, Nathanielsz, P.W. (1998) The effects of fetal adrenalectomy at 110 days gestational age and subsequent cortisol administration on CRH and AVP mRNA expression in the hypothalamic paraventricular nucleus of the ovine fetus. Dev Brain Res 106: 119-128.

Unno, N., Wu, W.X., Wong, C.H., Bennett, P.R., Shinozuka, N., Nathanielsz, P.W. (1998) Prostaglandin regulation of fetal plasma adrenocorticotropin and cortisol concentrations in late-gestation sheep. Biol Reprod 58(2): 514-519.

Wu, W.X., Bruns, M.E., Bruns, D., Seaner, R., Nathanielsz, P.W., Ferguson, J.E. (1998) Parathyroid hormone related protein (PTHrP) mRNA in sheep endometrium and myometrium during late gestation and labor. J Soc Gynecol Invest 5: 127-131.

Wu, W.X., Unno, N., Ma, X.H., Nathanielsz, P.W. (1998) Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep. Endocrinology 139: 3096-3103.

1997

Derks, J.B., Giussani, D.A., Jenkins, S.L., Wentworth, R.A., Visser, G.H.A., Padbury, J.F., Nathanielsz, P.W. (1997) A comparative study of the cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol 499(1): 217-226.

Giussani, D.A., Unno, N., Jenkins, S.L., Wentworth, R.A. Derks, J.B., Collins, J.H., Nathanielsz, P.W. (1997) Dynamics of the cardiovascular responses to repeated, partial umbilical cord compression in the late gestation sheep fetus. Am J Physiol Heart and Circ Physiol 42: H2351-H2360.

Unno, N., Giussani, D.A., Man A Hing, W.K.H., Ding, X-Y, Collins, J.H., Nathanielsz, P.W. (1997) Changes in ACTH and cortisol responsiveness following repeated partial umbilical cord occlusions in the late gestation ovine fetus. Endocrinology 138: 259-263.

Wu, W.X., Ma, X.H., Zhang, Q., Buchwalder, L.F., Nathanielsz, P.W. (1997) Regulation of prostaglandin endoperoxide H synthase 1 and 2 by estradiol and progesterone in nonpregnant ovine myometrium and endometrium in vivo. Endocrinology 138: 4005-4012.

1996

Derks, J.B., Giussani, D.A., Van Dam, L.M., Jenkins, S.L., Winter, J.A., Zhao, X.F., Hammond, G.L., Nathanielsz, P.W. (1996) Differential effects of betamethasone and dexamethasone fetal administration on parturition in sheep. J Society for Gynecol Invest 3: 336-341.

Pomerantz, J.E., Li, C., Nathanielsz, P.W., McDonald, T.J. (1996) Corticotropin-releasing hormone axons in the adrenal glands of fetal and postnatal sheep. J Autonomic Nervous System 59: 87-90.

Robertson, S.S., Johnson, S.L., Bacher, L.F., Wood, J.R., Wong, C.H., Robinson, S.R., Smotherman, W.P., Nathanielsz, P.W. (1996) Contractile activity of the uterus prior to labor alters the temporal organization of spontaneous motor activity in the fetal sheep. Developmental Psychobiol 29(8): 667-683.

Wu, W.X., Derks, J.B., Nathanielsz, P.W. (1996) Effects of glucocorticoids on estrogen receptor messenger ribonucleic acid in the pregnant ovine myometrium in vivo and in vitro. Biol Reprod 54: 230-241.

Wu, W.X., Derks, J.B., Zhang, Q. Nathanielsz, P.W. (1996) Changes in heat shock protein 90 and 70 messenger ribonucleic acid in uterine tissues of the ewe in relation to parturition and regulation by estradiol and progesterone. Endocrinology 137: 5685-5693.

Wu, W.X., Owiny, J.R., Zhang, Q., Ma, X.H., Nathanielsz, P.W. (1996) Regulation of the estrogen receptor and its mRNA in the ovariectomized sheep myometrium and endometrium: The role of estradiol and progesterone. Biol Reprod 555: 762-768.

Wu, W.X., Verbalis, J.G., Hoffman, G.E., Derks, J.B., Nathanielsz, P.W. (1996) Characterization of oxytocin receptor (OTR) expression and distribution in the pregnant sheep uterus. Endocrinology 137: 722-728.

Zhang, Q, Wu, W.X., Derks, J.B. Brenna, J.T., Nathanielsz, P.W. (1996) The expression of cytosolic phospholipase A2 (cPLA2) and prostaglandin endoperoxide synthase (PGHS) in ovine maternal uterine and fetal tissues during late gestation and labor. Endocrinology 137: 4010-4017.

1995

Owiny, J.R., Gilbert, R.O., Wahl, C.H., Nathanielsz, P.W. (1995) Leukocytic invasion of the ovine cervix at parturition. J Soc Gynecol Invest 2: 593-96.

Owiny, J.R., Jenkins, S.L., Sadowsky, D.W., Nathanielsz, P.W. (1995) Effect of pulsatile oxytocin administration to the pregnant ewe in the last third of gestation on fetal ACTH and cortisol response to acute hypoxemia. J Soc Gynecol Invest 2: 673-677.

Owiny, J.R., Sadowsky, D.W., Zarzeczny, S., Nathanielsz, P.W. (1995) Effect of pulsatile oxytocin administration to the pregnant sheep over the last third of gestation on fetal ACTH and cortisol response to hypotension. J Soc Gynecol Invest 2(1): 13-18.

Robinson, S.R., Wong, C.H., Robertson, S.S., Nathanielsz, P.W., Smotherman, W.P. (1995) Behavioral responses of the chronically-instrumented sheep fetus to chemosensory stimuli presented in utero. Behavioral Neurosciences 109(3): 551-562.

Wimsatt, J., Myers, D.A., Myers, T.R., Nathanielsz, P.W. (1995) Prostaglandin synthase activity of fetal sheep cotyledons at 122 days of gestation and term: Is expression of prostaglandin synthetic capacity in fetal cotyledonary tissue near labor location dependent? Biol Reprod 52: 737-744.

Wimsatt J., Nathanielsz, P.W. (1995) Prostaglandin H synthase activity in the sheep placenta during cortisol induced labor at 128-131 days of gestation and during cortisol induced labor at 128-131 days of gestation and during spontaneous delivery at term. Prostaglandins, Leukotrienes, and Essential Fatty Acids 53(1): 53-58.

Wu, W.X., Myers, D.A., Nathanielsz, P.W. (1995) Changes in estrogen receptor mRNA in sheep fetal and maternal tissues during late gestation and labor. Am J Obstet Gynecol 172: 844-850.

Zhang, Q., Wu, W.X., Nathanielsz, P.W., Brenna, J.T. (1995) Distribution of arachidonic, eicosapentaenoic, docosahexaenoic and related fatty acids in ovine endometrial phospholipids in late gestation and labor. Prostaglandins, Leukotrienes, and Essential Fatty Acids 53: 201-209.

Zhang, Q., Wu, W.X., Nathanielsz, P.W., Brenna, J.T. (1995) Distribution and mobilization of arachidonic, eicosapentaenoic, docosahexaenoic and related fatty acids in ovine endometrial phospholipids in late gestation and labor. Prostaglandins, Leukotrienes and Essential Fatty Acids 53: 201-209.

Human Investigations

2011

Carter MF, Powell TL, Li C, Myatt L, Dudley D, Nathanielsz PW, Jansson T (2011) Fetal serum folate concentrations and placental folate transport in obese women. Am J Obstet Gynecol 205(1): 83.e17–83.e25. PMID 21514551.

2010

Farley D.M., Choi J., Dudley D.J., Li C., Jenkins S.L., Myatt L., Nathanielsz P.W. (2010) Placental amino acid transport and placental leptin resistance in pregnancies complicated by maternal obesity. Placenta 31(8): 718-24. PMID 20609473.

2006

Roman, A.S., Schreher, J., Mackenzie, A.P., Nathanielsz, P.W. (2006) Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta. Am J Obstet Gynecol 195(6): 1693–1699.

1999

Nathanielsz, P.W., Smith, G.C.S. (1999) Labor and Delivery, Human. In: Encyclopedia of Reproduction, Vol. 2. Academic Press. Pp. 943-950.

Multiple Species Investigations

2014

Shehab, M.A., Damerill, I., Shen, T., Rosario, F.J., Nijland, M., Nathanielsz, P.W., Kamat, A., Jansson, T., Gupta, M.B. (2014) Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. Endocrinology 155(4): 1327-39. PMID: 24437487.

Zambrano E, Guzmán C, Rodríguez-González GL, Durand-Carbajal M, Nathanielsz PW. (2014) Fetal programming of sexual development and reproductive function. Mol Cell Endocrinol 382(1): 538-49. PMID 24045010.

2013

Dong, M., Zheng, Q., Ford, S. P., Nathanielsz, P. W., & Ren, J. (2013) Maternal obesity, lipotoxicity and cardiovascular diseases in offspring. J Mol Cell Cardiol 55, 111–116. PMID 22982026.

Kyathanahalli, C., Marks, J., Nye, K., Lao, B., Albrecht, E.D., Aberdeen, G.W., Nathanielsz, P.W., Jeyasuria, P., Condon, J.C. (2013) Cross-Species Withdrawal of MCL1 Facilitates Postpartum Uterine Involution in Both the Mouse and Baboon. Endocrinology 154(12): 4873–4884. PMID 24140717.

Nathanielsz, P.W., Ford, S.P., Long, N.M., Vega, C.C., Reyes-Castro, L.A. and Zambrano, E. (2013) Interventions to prevent adverse fetal programming due to maternal obesity during pregnancy. Nutr Rev 71 Suppl 1, S78-S87. PMID 24147928.

Rabadan-Diehl C, Nathanielsz PW (2013) From mice to men: research models of developmental programming. J Dev Orig Health Dis 4(1): 3-9. PMID 23525085.

Zambrano, E., Nathanielsz, P.W. (2013) Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies. Nutr Rev 71(Suppl 1): S42-S54. PMID 24147924.

2012

Cowley, A. W., Nadeau, J. H., Baccarelli, A., Berecek, K., Fornage, M., Gibbons, G. H., Harrison, D. G., Liang, M., Nathanielsz, P. W., O’Connor, D. T., Ordovas, J., Peng, W., Soares, M. B., Szyf, M., Tolunay, H. E., Wood, K. C., Zhao, K., Galis, Z. S. (2012) Report of the national heart, lung, and blood institute working group on epigenetics and hypertension. Hypertension 59: 899-905.

2008

Nijland, M.J., Ford, S.P., Nathanielsz, P.W. (2008) Prenatal origins of adult disease. Curr Opin Obstet Gynecol 20(2): 132-138.

2007

Cox, L.A., Nathanielsz, P.W. (2007) Importance of genetic differences in developmental programming: gene by environment interactions in models of maternal dietary restriction. J Physiol 581(Pt 2): 421-2. PMID 17379628.

Nathanielsz, P.W., Poston, L., Taylor, P.D. (2007) In utero exposure to maternal obesity and diabetes: animal models that identify and characterize implications for future health. Clin Perinatol 34(4): 515-526.

Nathanielsz, PW, Poston L, Taylor, PD (2007) In utero exposure to maternal obesity and diabetes: animal models that identify and characterize implications for future health. Obstet Gynecol Clin North Am 34(2): 201-12.

2006

Nathanielsz, P.W. (2006) Animal models that elucidate basic principles of the developmental origins of adult diseases. ILAR J 47(1): 73-82.

Nathanielsz, P.W., Padmanabhan, V. (2006) Developmental Origin of Health and Disease. J Physiol 572: 3-4.

2004

Armitage JA, Khan IY, Taylor PD, Nathanielsz PW, Poston L. (2004) Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? J Physiol 561: 355-377.

Samtani MN, Schwab M, Nathanielsz PW, Jusko WJ. (2004) Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats. Pharm Res 21(12): 2279-92.

2003

Dudley, D.J., Waters, T.P., Nathanielsz, P.W. (2003) Current status of single-course antenatal steroid therapy. Clinical Obstetrics and Gynecology 46: 132-149.

Nathanielsz, P.W. (2003) Fetal Programming. J Bellevue Obstetrical and Gynecological Society. Vol. XIX, Pp. 1-15.

Nathanielsz, P.W., Berghorn, K.A., Derks, .B., Giussani, D.A., Docherty, C., Unno, N., Davenport, A., Kutzler, M., Koenen, S., Visser, G.H., Nijland, M.J. (2003) Life before birth: effects of cortisol on future cardiovascular and metabolic function. Acta Paediatr 92(7): 766-772.

Nathanielsz, P.W., Hanson, M.A. (2003) The fetal dilemma: spare the brain and spoil the liver. J Physiol 548(pt.2): 333.

Nathanielsz, P.W., Thornburg, K.L. (2003) Fetal Programming: from gene to functional systems—an overview. J Physiol 547(1): 3-4.

2001

Smith, G.C., Wu, W.X., Nijland, M.J., Koenen, S.V., Nathanielsz, P.W. (2001) Effect of gestational age, corticosteroids, and birth on expression of prostanoid EP receptor genes in lamb and baboon ductus arteriosus. J Cardiovasc Pharmacol 37(6): 697-704.

2000

Berghorn, K.A., Li, C., Nathanielsz, P.W., McDonald, T.J. (2000) VIP innervation: Sharp contrast in fetal sheep and baboon adrenal glands suggests differences in developmental regulation. Brain Res 877(2): 271-280.

Ma, Y., Lockwood, C.J., Bunim, A.L., Giussani, D.A., Nathanielsz, P.W., Guller, S. (2000) Cell type specific regulation of fetal fibronectin expression in amnion: conservation of glucocorticoid responsiveness in human and nonhuman primates. Biol Reprod 62(6): 1812-7.

Nathanielsz, P.W. (2000) Fetal programming: How the quality of fetal life alters our biology for a lifetime. NeoReviews 1: E126-E131.

Nathanielsz, P.W., Smith, G.C.S. (2000) Regulation of the myometrium: term and preterm labor. Yrbk Obstet Gynaecol 8: 181-193.

1999

Nathanielsz, P.W. (1999) Effects of the intrauterine environment on the development of Diabetes. In: Pennington Center Nutrition Series: Nutrition, Genetics and Obesity (Vol. 9). Bray, GA and Ryan, DH., eds. Lousiana State University Press: Baton Rouge. Pp. 14-24.

1998

McDonald, T.J., Nathanielsz, P.W. (1998) The involvement of innervation in the regulation of fetal adrenal steroidogenesis. Horm Metab Res 30: 297-302.

Nathanielsz, P.W. (1998) Comparative studies on the initiation of labor. Eur J Obstet Gynecol and Reprod Biol 78: 127-132.

Nathanielsz, P.W. (1998) The role of estrogen in labor and delivery in primates and other species. Prenat Neonat Med 3: 64-67.

1997

Nathanielsz, P.W. (1997) Intra-uterine programming van de gezondheid. Nature or Nurture? Exogene invloeden op de prenatale ontwikkeling. Benelux Press. Pp. 6-13.

1996

Nathanielsz, P.W. (1996) The Timing of Birth. American Scientist. Pp. 562-569.

1995

Garcia-Villar, R., Green, L.R., Jenkins, S.L., Wentworth, R.A., Coleman, R.A., Nathanielsz, P.W. (1995) Evidence for the presence of AH 13205-sensitive EP2-prostanoid receptors in the pregnant baboon but not in the pregnant sheep myometrium near term. J Soc Gynecol Invest 2(1): 6-12.