March 2016: TPLH Researchers Win Award from the Society for Reproductive Investigation Two Years in a Row

We are proud to announce that TPLH Postdoctoral Researcher Dr. Shanshan Yang won a 2016 Pfizer President’s Presenter Award from the Society for Reproductive Investigation (SRI). Dr. Yang’s research demonstrated changes to the brains of baboon offspring of obese mothers. These changes to neurotransmitters may predispose offspring of obese mothers to depression and anxiety.

This is the second year in a row a TPLH postdoc has taken home a prize from SRI. Last year, Dr. Ablat Tursun received a 2015 Pfizer President’s Presenter Award for his research into oxidative stress in the pancreas of baboons with intrauterine growth restriction (IUGR) as a result of low maternal nutrition.

These findings make an important contribution to our understanding of how maternal nutrition during pregnancy influences offspring health. TPLH and close collaborators gave 5 oral presentations and 16 poster presentations at the 2016 SRI meeting. The majority of these focused on the effects of maternal over-nutrition and under-nutrition during pregnancy on the lifetime health of offspring.

TPLH has an extensive collaboration with Dr. Elena Zambrano at the Mexican National Institute of Medical Sciences and Nutrition. Dr. Zambrano’s group, in collaboration with TPLH, won two 2016 Pfizer President’s Presenter Awards at SRI for their work showing increased oxidative stress in rat offspring of under-nourished and over-nourished mothers. The awards were presented to Dr. Consuelo Lomas-Soria and doctoral candidate Guadalupe L. Rodriguez-Gonzalez. Their work with rat models of maternal nutrition lays the foundation for work by TPLH in baboon models.

Follow this link for the full issue of Reproductive Sciences in which all meeting abstracts are published: http://rsx.sagepub.com/content/23/1_suppl.toc

award-winners-together-2016
Photo above: SRI 2016 Awards winners and their sponsors. From left to right, Elena Zambrano, Cun Li, Guadalupe L. Rodriguez-Gonzalez, Consuelo Lomas-Soria, Peter W Nathanielsz, and Shanshan Yang.

Presentations to the Society for Reproductive Investigation Montreal 2016

By TPLH and Close Collaborators

Oral presentations:

Franke K, Dahnke R, Clarke GD, Kuo AD, Li C, Schwab M, Gaser C, Nathanielsz PW (2016) Intra-uterine growth restriction (IUGR) accelerates offspring brain aging. Reproductive Sci 23(1 Suppl), p. 72A [Abstract O-062].

Young Investigator Prize. Lomas-Soria C, Bautista CJ, Reyes-Castro LA, Vega C, Rodriguez-Gonzalez GL, Beltran-Ramirez A, Cox LA, Nathanielsz PW and Zambrano E (2016) Male offspring (OFF) of obese mothers exhibit increased oxidative stress (OS) and hepatic steatosis exacerbated by aging. Reproductive Sci 23(1 Suppl), p. 55A [Abstract O-009].

Young Investigator Prize. Rodriguez-Gonzalea GL, Vega CC, Reyes-Castro LA, Boeck L, Ibanez C, Nathanielsz PW, Larrea F, and Zambrano E (2016) Maternal protein restriction (MPR) during pregnancy increases sperm oxidative stress (OS) and accelerates aging of sperm quality and reproductive capacity in the male rat offspring (OFF). Reproductive Sci 23(1 Suppl), p. 72A [Abstract O-063].

Serafim TL, Cunha-Oliveira T, Deus CM, Oliveira PJ, Yang S, Tuerxun A, Odhiambo F, Ghnenis AB, Smith AM, Li J, Nathanielsz PW, and Ford SP (2016) Maternal obesity (MO) in sheep decreases fetal hepatic mitochondrial respiratory chain activity. Reproductive Sci 23(1 Suppl), p. [Abstract O-132].

Young Investigator Prize. Yang S, Nathanielsz PW, Li J, Li C (2016) Maternal obesity (MO) up-regulates protein associated with stress in the late gestation baboon fetal frontal cortex. Reproductive Reproductive Sci 23(1 Suppl), p. [Abstract O-129].

Poster Presentations:

Bautista CJ, Rodriguez-Gonzalez GL, Hernandez A, Reyes-Castro LA, Neri A, Nathanielsz PW, Zambrano E (2016) In the rat consumption of vegetable or animal protein diets in pregnancy and lactation alter milk composition and offspring outcomes. Reproductive Sci 23(1 Suppl), p. 150A [Abstract T-158].

Clarke GD, Li J, Kuo AH, Cox LA, Li C, Nathanielsz PW (2016) Maternal antenatal glucocorticoid administration doubles pericardial fat and increases liver lipids five fold in adult baboon offspring at a human equivalent age of 40 years. Reproductive Sci 23(1 Suppl), p. 107A [Abstract T-018].

Guida SM, Ghnenis AB, Odhiambo JF, Bell CJ, Nathanielsz PW, Ford SP (2016) Maternal overnutrition/obesity (MO) increases fetal liver mRNA and protein expression of acetyl-CoA carboxylase alpha (ACCa) in association with altered ACACA gene methylation on day 135 of gestation in sheep. Reproductive Sci 23(1 Suppl), p. 278A [Abstract S-026].

Huber HF, Bartlett TQ, Smith BK, Li C, Jenkins SJ, Nathanielsz PW (2016) Birth sex ratio in baboon mothers fed ad lib, reduced or obesogenic diet. Reproductive Sci 23(1 Suppl), p. 236A [Abstract F-161].

Kuo, AH, Huber HF Li C, Li J, Nathanielsz PW, Clarke G (2016) Accelerated right heart aging in IUGR offspring of undernourished pregnant baboons. Reproductive Sci 23(1 Suppl), p. 147A [Abstract T-149].

Jenkins SL, Nijland MJ, Maloyan A, Myatt L, Vega S, Rios S, Avila M, Li C, the late McDonald TJ, Huber HH, Cox LA, Nathanielsz PW (2016) Phenotype in a nonhuman primate (NHP) model of programming by maternal obesity (MO) and high-energy diet (HED). Reproductive Sci 23(1 Suppl), p. 316A [Abstract S-151].

Jenkins SJ, Nijland MJ, Vega S, Rios S, Avila M, Li C, the late McDonald TJ, Huber HF, Cox LA, Nathanielsz PW (2016) Growth trajectory and prenatal and postnatal phenotype in a nonhuman primate (NHP) model of IUGR Reproductive Sci 23(1 Suppl), p. 149A [Abstract T-156].

Li J, Kuo AH, Huber HF, Li C, Nathanielsz PW, Clarke GD (2016) Antenatal glucocorticoid administration alters cardiac function in baboon offspring. Reproductive Sci 23(1 Suppl), p. 274A  [Abstract S-016].

Li C, Yang S, Xie D, Li J, Nathanielsz PW (2016) Increased oxidative stress (OS) at 90% (0.9) of gestation (G) in the frontal cortex (FC) of fetuses of obese baboons on a high energy diet. Reproductive Sci 23(1 Suppl), p. 145A [Abstract T-141].

Li J, Yang S, Xie D, Clarke GD, Nathanielsz PW, Li C (2016) Sex-specific activation of fibrosis pathways in the IUGR fetal baboon heart and skeletal muscle at 0.9 of gestation (G). Reproductive Sci 23(1 Suppl), p. 148A [Abstract T-153].

Pantham P, Rosario FJ, Weintraub S, Nathanielsz PW, Powell TL, Li C, Jansson T (2016) Down-Regulation of Placental Amino Acid Transport Precedes the Development of Intrauterine Growth Restriction in Response to Maternal Nutrient Restriction in Baboons. Reproductive Sci 23(1 Suppl), p. 234A [Abstract F-157].

Reyes-Castro LA, Padilla-Gomez E, Quirarte G, Diaz-Cintra S, Rodriguez-Gonzalez GL, Nathanielsz PW, Zambrano E (2016) Hippocampal neuronal mechanisms in impaired spatial memory and learning in rat offspring of mothers exposed to maternal protein restriction (MPR) during pregnancy. Reproductive Sci 23(1 Suppl), p. 235A [Abstract F-160].

Rosario FJ, Nathanielsz PW, Li ,C, Powell TL, Jansson T (2016) Impaired trophoblast nutrient transport following maternal nutrient restriction (MNR) in the baboon is alleviated by activation of mTOR signaling. Reproductive Sci 23(1 Suppl), p. 324A [Abstract S-180].

Tuerxun A, Li C, Nathanielsz PW (2016) Maternal obesity increases oxidative stress in fetal baboon pancreas in late gestation (G). Reproductive Sci 23(1 Suppl), p. 193A [Abstract F-024].

Wang Q, Hu N, Zhu C, Ford SP, Nathanielsz PW, Ren J, Guo W (2016) Impact of maternal obesity and overnutrition on fetal cardiac function in sheep. Reproductive Sci 23(1 Suppl), p. 233A [Abstract F-153].

Zhu C, Odhiambo F, Ghnenis AB, Ford SP, Nathanielsz PW, Ren J, Guo W (2016) Maternal obesity (OB) increases the stiffer, shorter titin isoform in the maternal and fetal heart. Reproductive Sci 23(1 Suppl), p. 146A [Abstract T-147].