Dr. Thippeshappa’s research experience is in HIV biology and vaccine immunology. He has a strong research interest in HIV vaccine development, cure research, and development of macaque models for HIV-1 infection/AIDS. His primary research focus is to develop a nonhuman primate (NHP) model for HIV-1 infection/AIDS, and to understand the barriers that prevent cross-species transmission of HIV-1 to macaques. He is also interested in understanding immune responses to pathogens and using that knowledge to develop novel therapeutics and vaccine strategies. His research projects focus on developing muscosal immunization strategies for delivery of HIV vaccines.
Inside the Lab
In Dr. Kaushal’s lab, Dr. Thippeshappa is involved with multiple research projects that utilize SIV/Mtb (Mycobacterium tuberculosis) co-infection in nonhuman primate models.
He is working on developing a rhesus macaque model of Mtb/SHIV co-infection that can recapitulate how HIV-1 infection induces reactivation of latent TB in individuals infected with HIV-1.
He is also interested in testing novel attenuated vectors for HIV-1 vaccine development.
Main Technologies and Methods Used
- Construction of infectious HIV molecular clones
- Immunology, virology and molecular biology techniques to understand vaccine-induced immune responses in macaques