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Human Neutralizing Antibodies Against Sars-cov-2 Spike S2 Domain And Uses Thereof


The disclosure is based, at least in part, on certain human monoclonal antibodies , or antigen binding fragments thereof, having unexpected broad neutralizing activities against SARS – CoV – 2. The disclosed antibodies and/or antigen-binding fragments thereof are therapeutic agents for the treatment of SARS – CoV – 2 infections and are suitable for use in therapeutic methods to protect individuals from SARS – CoV – 2 infections.

Application Number


Date of Application

June 9, 2022


James Kobie, Michael Piepenbrink, Paul Gopefert, Mark R. Walter, Nathan Erdmann, Ashlesha Deshpande, Luis Martinez-Sobrido and Jun-Gyu Park