Research Focus
Sarah Hussein Mahmoud Hussein, PhD, is a Staff Scientist in the Gauduin Lab within the Research Program of Disease Intervention & Prevention at Texas Biomedical Research Institute and an Associate Professor of Virology and Immunology at the National Research Centre in Egypt. She is a virologist, immunologist, and molecular biologist whose work focuses on translational vaccine research, vector design, and antibody-based countermeasures for respiratory, emerging, and zoonotic viruses.
At Texas Biomed, Dr. Mahmoud’s research centers on innovative mucosal vaccine platforms and next-generation vectors targeting infectious diseases, including influenza viruses, SARS-CoV-2, HIV, HPV, RSV, and other high-consequence pathogens. She also contributes to multivalent subunit vaccine projects that combine antigens from multiple respiratory viruses into a single formulation to broaden protection and simplify immunization strategies. Her work further encompasses the discovery and characterization of broadly protective human monoclonal antibodies, including antibodies with cross-reactive activity against diverse influenza neuraminidases (H5N1, H1N1, H3N2), and the development of advanced viral models supporting preclinical evaluation of vaccines and antivirals.
Before her current role, Dr. Mahmoud played key roles in Egypt in designing and evaluating recombinant bivalent influenza-MERS vaccine candidates, multivalent fowl adenovirus-Newcastle disease vaccines, and in defining the pathogenicity of highly pathogenic avian influenza A/H5Nx viruses in avian and murine models. Collectively, these efforts have contributed to expanding vaccine platform technologies and antiviral strategies for both human and animal health.