Dr. Lee’s research focuses on immune correlates associated with risk of disease progression and inflammation during tuberculosis (TB). His special interest is to Identify the role for innate lymphoid cells (ILCs) including natural killer (NK) cells in determining the outcome of disease during TB. Dr. Lee oversees the Biology Core at the Southwest National Primate Research Center at Texas Biomedical Research Institute.
Inside the Lab
In Dr. Deepak Kaushal’s lab, Dr. Lee studies on the role of ILCs including NK cells in control of Mycobacterium tuberculosis infection using the nonhuman primate model.
Another focus of Dr. Lee’s research is to investigate the impact of high-risk factors (e.g., HIV, diabetes, smoking) on recurrent TB, with a concentration on the role for NK cells in latent TB reactivation.
He is also interested in harnessing the adaptive features of NK cells to augment vaccine efficacy and improve the clinical outcome of tuberculosis.
Main Technologies and Methods Used
- Flow cytometry
- Confocal microscopy
- Transcriptomics including RNAseq
- Assays for cell-mediated immune responses